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- W4383959462 abstract "Articular cartilage has limited intrinsic ability for self-regeneration, and treatments to restore fully functional cartilage remain a challenge. Mesenchymal stem cells (MSCs), given their relative ease of derivation, proliferative capacity, and differentiation potential, offer a promising alternative therapeutic approach for cartilage repair. Despite numerous efforts evaluating various factors such as culture conditions, differentiation cocktails, and properties of three-dimensional (3D) substrates, MSC-based approaches for cartilage repair have yet to achieve the consistency and effectiveness for widespread clinical use. MSC-derived cartilage tissue does not resemble physiological cartilage, typically yielding mixed hyaline/fibrocartilaginous phenotypes, with inherent tendency toward hypertrophy. The regenerated neocartilage suffers from sub-optimal biochemical content and mechanical strength, in comparison with chondrocyte-derived tissue. Further, the lack of a hierarchical architecture with zonal cellular and extracellular matrix composition and properties in the engineered tissue limits the restoration of normal tissue function. This chapter provides an overview of key approaches for manipulating chondrogenic differentiation of MSCs, with emphasis on recent progress in (1) the enhancement of extracellular matrix (ECM) and mechanical strength of neocartilage tissue; (2) the prevention of cartilage hypertrophy; and (3) the generation of phenotypically distinct cartilage. Critical insights on refining regenerative approaches for articular cartilage repair, such as the requisite composition and amenability of 3D matrices for dynamic cellular and morphogenetic events, are addressed." @default.
- W4383959462 created "2023-07-12" @default.
- W4383959462 creator A5006285787 @default.
- W4383959462 creator A5012130337 @default.
- W4383959462 creator A5023200882 @default.
- W4383959462 creator A5079349623 @default.
- W4383959462 date "2023-01-01" @default.
- W4383959462 modified "2023-09-23" @default.
- W4383959462 title "Strategies to Control Mesenchymal Stem Cell Differentiation for Regenerating Phenotypically Defined Articular Cartilage" @default.
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