FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4383960779> ?p ?o ?g. }

• W4383960779 endingPage "222" @default.
• W4383960779 startingPage "212" @default.
• W4383960779 abstract "Extracorporeal life support (ECLS) devices are lifesaving for critically ill patients with multi-organ dysfunction. Despite this, patients supported with ECLS are at high risk for ECLS-related complications, including nosocomial infections, and mortality rates are high in this patient population. The high mortality rates are suspected to be, in part, a result of significantly altered drug disposition by the ECLS circuit, resulting in suboptimal antimicrobial dosing. Cefepime is commonly used in critically ill patients with serious infections. Cefepime dosing is not routinely guided by therapeutic drug monitoring and treatment success is dependent upon the percentage of time of the dosing interval that the drug concentration remains above the minimum inhibitory concentration of the organism. This ex vivo study measured the extraction of cefepime by continuous renal replacement therapy (CRRT) and extracorporeal membrane oxygenation (ECMO) circuits. Cefepime was studied in four closed-loop CRRT circuit configurations and a single closed-loop ECMO circuit configuration. Circuits were primed with a physiologic human blood–plasma mixture and the drug was dosed to achieve therapeutic concentrations. Serial blood samples were collected over time and concentrations were quantified using validated assays. In ex vivo CRRT experiments, cefepime was rapidly cleared by dialysis, hemofiltration, and hemodiafiltration, with greater than 96% cefepime eliminated from the circuit by 2 hours. In the ECMO circuits, the mean recovery of cefepime was similar in both circuit and standard control. Mean (standard deviation) recovery of cefepime in the ECMO circuits ( n = 6) was 39.2% (8.0) at 24 hours. Mean recovery in the standard control ( n = 3) at 24 hours was 52.2% (1.5). Cefepime is rapidly cleared by dialysis, hemofiltration, and hemodiafiltration in the CRRT circuit but minimally adsorbed by either the CRRT or ECMO circuits. Dosing adjustments are needed for patients supported with CRRT." @default.
• W4383960779 created "2023-07-12" @default.
• W4383960779 creator A5001352183 @default.
• W4383960779 creator A5043617520 @default.
• W4383960779 creator A5049972729 @default.
• W4383960779 creator A5052191475 @default.
• W4383960779 creator A5052894330 @default.
• W4383960779 creator A5082697782 @default.
• W4383960779 date "2022-09-01" @default.
• W4383960779 modified "2023-10-16" @default.
• W4383960779 title "Cefepime Extraction by Extracorporeal Life Support Circuits" @default.
• W4383960779 cites W1489109828 @default.
• W4383960779 cites W1581935460 @default.
• W4383960779 cites W1905796456 @default.
• W4383960779 cites W1972750978 @default.
• W4383960779 cites W1989630422 @default.
• W4383960779 cites W1998310952 @default.
• W4383960779 cites W2006867331 @default.
• W4383960779 cites W2010192221 @default.
• W4383960779 cites W2011627328 @default.
• W4383960779 cites W2014603335 @default.
• W4383960779 cites W2024210192 @default.
• W4383960779 cites W2039754485 @default.
• W4383960779 cites W2060635944 @default.
• W4383960779 cites W2063576651 @default.
• W4383960779 cites W2066608027 @default.
• W4383960779 cites W2081954140 @default.
• W4383960779 cites W2084207274 @default.
• W4383960779 cites W2102130358 @default.
• W4383960779 cites W2102549562 @default.
• W4383960779 cites W2110119221 @default.
• W4383960779 cites W2125652257 @default.
• W4383960779 cites W2135206411 @default.
• W4383960779 cites W2139809453 @default.
• W4383960779 cites W2144584318 @default.
• W4383960779 cites W2148500450 @default.
• W4383960779 cites W2151580334 @default.
• W4383960779 cites W2152986721 @default.
• W4383960779 cites W2159272981 @default.
• W4383960779 cites W2162892700 @default.
• W4383960779 cites W2163622137 @default.
• W4383960779 cites W2168610454 @default.
• W4383960779 cites W2282412776 @default.
• W4383960779 cites W2462837491 @default.
• W4383960779 cites W2511809475 @default.
• W4383960779 cites W2591157472 @default.
• W4383960779 cites W2770585743 @default.
• W4383960779 cites W2795285953 @default.
• W4383960779 cites W2885078137 @default.
• W4383960779 cites W2891539841 @default.
• W4383960779 cites W2901002893 @default.
• W4383960779 cites W2911634754 @default.
• W4383960779 cites W2976075997 @default.
• W4383960779 cites W2980375444 @default.
• W4383960779 cites W3001437512 @default.
• W4383960779 cites W3014872337 @default.
• W4383960779 cites W3021794106 @default.
• W4383960779 cites W3022327571 @default.
• W4383960779 cites W3091943793 @default.
• W4383960779 cites W3094978576 @default.
• W4383960779 cites W3107168012 @default.
• W4383960779 cites W3108945826 @default.
• W4383960779 cites W3116494079 @default.
• W4383960779 cites W3123685372 @default.
• W4383960779 cites W4220653715 @default.
• W4383960779 cites W4226276854 @default.
• W4383960779 doi "https://doi.org/10.1051/ject/202254212" @default.
• W4383960779 hasPublicationYear "2022" @default.
• W4383960779 type Work @default.
• W4383960779 citedByCount "0" @default.
• W4383960779 crossrefType "journal-article" @default.
• W4383960779 hasAuthorship W4383960779A5001352183 @default.
• W4383960779 hasAuthorship W4383960779A5043617520 @default.
• W4383960779 hasAuthorship W4383960779A5049972729 @default.
• W4383960779 hasAuthorship W4383960779A5052191475 @default.
• W4383960779 hasAuthorship W4383960779A5052894330 @default.
• W4383960779 hasAuthorship W4383960779A5082697782 @default.
• W4383960779 hasBestOaLocation W43839607791 @default.
• W4383960779 hasConcept C126322002 @default.
• W4383960779 hasConcept C177713679 @default.
• W4383960779 hasConcept C2776858399 @default.
• W4383960779 hasConcept C2776968632 @default.
• W4383960779 hasConcept C2777050379 @default.
• W4383960779 hasConcept C2777288759 @default.
• W4383960779 hasConcept C2777637488 @default.
• W4383960779 hasConcept C2778063415 @default.
• W4383960779 hasConcept C2778865887 @default.
• W4383960779 hasConcept C2779541074 @default.
• W4383960779 hasConcept C2779915274 @default.
• W4383960779 hasConcept C2908647359 @default.
• W4383960779 hasConcept C42219234 @default.
• W4383960779 hasConcept C523546767 @default.
• W4383960779 hasConcept C54355233 @default.
• W4383960779 hasConcept C71924100 @default.
• W4383960779 hasConcept C86803240 @default.
• W4383960779 hasConcept C98274493 @default.
• W4383960779 hasConcept C99454951 @default.
• W4383960779 hasConceptScore W4383960779C126322002 @default.

• next