FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4383961567> ?p ?o ?g. }

• W4383961567 endingPage "115238" @default.
• W4383961567 startingPage "115238" @default.
• W4383961567 abstract "Although adequate intake of manganese (Mn) is essential to humans, Mn in excess is neurotoxic. Exposure to extremely high doses of Mn results in manganism, a condition that exhibits Parkinson-like symptoms. However, the mechanisms underlying its neurotoxic effects in Mn-induced parkinsonism pathogenesis are unclear. In this study, 8-week-old male C57BL/6 J mice were injected intraperitoneally with saline and 50 mg/kg MnCl2 respectively once daily for 14 days to produce an acute Mn neurotoxicity model. Accumulation of Mn in the midbrain, motor dysfunction and loss of dopaminergic neurons in the substantia nigra evidenced Mn neurotoxicity. Untargeted lipidomic analysis demonstrated that Mn overexposure altered lipidome profiles. A significant modulation of 12 lipid subclasses belonging to 5 different categories were found in the midbrain and among the most abundant lipids were sphingolipids, glycerophospholipids, and glycerides. The levels of sphingomyelin (SM) were significantly decreased after Mn treatment. The expression of SM biosynthesis genes was decreased dramatically while sphingomyelinase was up-regulated. In addition, we observed oxidative stress in both the midbrain of mice and MN9D cells, indicated by the increase of MDA level, the decrease of reduced GSH level and the inhibition of SOD and GPx enzyme activities. There was a correlation between these changes and motor dysfunctions. Overall, our study is the first to use lipidomics techniques to explore the pathogenesis of Mn-induced parkinsonism in C57BL/6 J mice. Mn induced molecular events in the midbrain, such as lipid metabolism disorders, oxidative stress and dopaminergic neurons injury, may mechanistically play important roles in the pathogenesis of Parkinson-like symptoms. Moreover, these findings emphasize the necessity for reducing the health risk of environmental neurotoxic pollutants in relation to parkinsonism." @default.
• W4383961567 created "2023-07-12" @default.
• W4383961567 creator A5002458192 @default.
• W4383961567 creator A5008091519 @default.
• W4383961567 creator A5023517909 @default.
• W4383961567 creator A5029350038 @default.
• W4383961567 creator A5031720199 @default.
• W4383961567 creator A5033599023 @default.
• W4383961567 creator A5041937252 @default.
• W4383961567 creator A5050844960 @default.
• W4383961567 creator A5053520465 @default.
• W4383961567 creator A5065172118 @default.
• W4383961567 creator A5077712629 @default.
• W4383961567 date "2023-09-01" @default.
• W4383961567 modified "2023-10-09" @default.
• W4383961567 title "Manganese overexposure induces Parkinson-like symptoms, altered lipid signature and oxidative stress in C57BL/6 J mouse" @default.
• W4383961567 cites W1749911542 @default.
• W4383961567 cites W1982368211 @default.
• W4383961567 cites W2001003591 @default.
• W4383961567 cites W2001575125 @default.
• W4383961567 cites W2002837323 @default.
• W4383961567 cites W2004714156 @default.
• W4383961567 cites W2005689441 @default.
• W4383961567 cites W2008247752 @default.
• W4383961567 cites W2013338106 @default.
• W4383961567 cites W2043954203 @default.
• W4383961567 cites W2062564355 @default.
• W4383961567 cites W2074924623 @default.
• W4383961567 cites W2089365017 @default.
• W4383961567 cites W2089971899 @default.
• W4383961567 cites W2094631352 @default.
• W4383961567 cites W2117821054 @default.
• W4383961567 cites W2129805824 @default.
• W4383961567 cites W2150239086 @default.
• W4383961567 cites W2169989061 @default.
• W4383961567 cites W2341425010 @default.
• W4383961567 cites W2486975460 @default.
• W4383961567 cites W2620288954 @default.
• W4383961567 cites W2769679178 @default.
• W4383961567 cites W2889158355 @default.
• W4383961567 cites W2909458901 @default.
• W4383961567 cites W2926631246 @default.
• W4383961567 cites W2951903539 @default.
• W4383961567 cites W2982127316 @default.
• W4383961567 cites W2987770989 @default.
• W4383961567 cites W3003140379 @default.
• W4383961567 cites W3010914688 @default.
• W4383961567 cites W3025027052 @default.
• W4383961567 cites W3121582209 @default.
• W4383961567 cites W3151053079 @default.
• W4383961567 cites W3154386165 @default.
• W4383961567 cites W3165621883 @default.
• W4383961567 cites W3198638776 @default.
• W4383961567 cites W3203511541 @default.
• W4383961567 cites W3206241816 @default.
• W4383961567 cites W4211044101 @default.
• W4383961567 cites W4220896857 @default.
• W4383961567 cites W4221021106 @default.
• W4383961567 cites W4281667466 @default.
• W4383961567 cites W4293773533 @default.
• W4383961567 cites W4295011576 @default.
• W4383961567 cites W4297540025 @default.
• W4383961567 cites W4311955768 @default.
• W4383961567 cites W839847231 @default.
• W4383961567 doi "https://doi.org/10.1016/j.ecoenv.2023.115238" @default.
• W4383961567 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37441952" @default.
• W4383961567 hasPublicationYear "2023" @default.
• W4383961567 type Work @default.
• W4383961567 citedByCount "1" @default.
• W4383961567 crossrefType "journal-article" @default.
• W4383961567 hasAuthorship W4383961567A5002458192 @default.
• W4383961567 hasAuthorship W4383961567A5008091519 @default.
• W4383961567 hasAuthorship W4383961567A5023517909 @default.
• W4383961567 hasAuthorship W4383961567A5029350038 @default.
• W4383961567 hasAuthorship W4383961567A5031720199 @default.
• W4383961567 hasAuthorship W4383961567A5033599023 @default.
• W4383961567 hasAuthorship W4383961567A5041937252 @default.
• W4383961567 hasAuthorship W4383961567A5050844960 @default.
• W4383961567 hasAuthorship W4383961567A5053520465 @default.
• W4383961567 hasAuthorship W4383961567A5065172118 @default.
• W4383961567 hasAuthorship W4383961567A5077712629 @default.
• W4383961567 hasBestOaLocation W43839615671 @default.
• W4383961567 hasConcept C126322002 @default.
• W4383961567 hasConcept C134018914 @default.
• W4383961567 hasConcept C137183658 @default.
• W4383961567 hasConcept C159167319 @default.
• W4383961567 hasConcept C181199279 @default.
• W4383961567 hasConcept C185592680 @default.
• W4383961567 hasConcept C25498285 @default.
• W4383961567 hasConcept C2776151105 @default.
• W4383961567 hasConcept C2776525014 @default.
• W4383961567 hasConcept C2778163477 @default.
• W4383961567 hasConcept C2779134260 @default.
• W4383961567 hasConcept C2779491297 @default.
• W4383961567 hasConcept C2780938664 @default.
• W4383961567 hasConcept C2780942790 @default.
• W4383961567 hasConcept C29730261 @default.
• W4383961567 hasConcept C513476851 @default.

• next