FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4383998082> ?p ?o ?g. }

• W4383998082 abstract "Benzo(a)pyrene-7,8-dihydrodiol-9,10-epoxide (BPDE), the metabolite of environmental pollutant benzo(a)pyrene (B(a)P) could induce pulmonary toxicity and inflammation. SIRT1, an NAD+ -dependent histone deacetylase, is known to regulate inflammation in the occurrence and development of various diseases, but its effects on BPDE-induced acute lung injury are still unknown. The present study aimed to explore the role of SIRT1 in BPDE-induced acute lung injury. Here, human bronchial epithelial (HBE) cells (BEAS-2B) cells were stimulated with BPDE at different concentrations (0.50, 0.75, and 1.00 μmol/L) for 24 h, we found that the levels of cytokines in the supernatant were increased and the expression of SIRT1 in cells was down-regulated, at the same time, BPDE stimulation up-regulated the protein expression of HMGB1, TLR4, and p-NF-κBp65 in BEAS-2B cells. Then the activator and inhibitor of SIRT1 were used before BPDE exposure, it was shown that the activation of SIRT1 significantly attenuated the levels of inflammatory cytokines and HMGB1, and reduced the expression of HMGB1, AC-HMGB1, TLR4, and p-NF-κBp65 protein; while these results were reversed by the inhibition of SIRT1. This study revealed that the SIRT1 activation may protect against BPDE-induced inflammatory damage in BEAS-2B cells by regulating the HMGB1/TLR4/NF-κB pathway." @default.
• W4383998082 created "2023-07-13" @default.
• W4383998082 creator A5014556310 @default.
• W4383998082 creator A5014624359 @default.
• W4383998082 creator A5026362839 @default.
• W4383998082 creator A5037014628 @default.
• W4383998082 creator A5041753664 @default.
• W4383998082 creator A5065683417 @default.
• W4383998082 creator A5075874833 @default.
• W4383998082 creator A5076036497 @default.
• W4383998082 creator A5079237288 @default.
• W4383998082 creator A5083311955 @default.
• W4383998082 creator A5085908543 @default.
• W4383998082 date "2023-07-12" @default.
• W4383998082 modified "2023-10-18" @default.
• W4383998082 title "The activation of <scp>SIRT1</scp> ameliorates <scp>BPDE‐induced</scp> inflammatory damage in <scp>BEAS‐2B</scp> cells via <scp>HMGB1</scp>/<scp>TLR4</scp>/<scp>NF‐κB</scp> pathway" @default.
• W4383998082 cites W1612531854 @default.
• W4383998082 cites W1978302160 @default.
• W4383998082 cites W1979504051 @default.
• W4383998082 cites W2024284705 @default.
• W4383998082 cites W2040047879 @default.
• W4383998082 cites W2056564149 @default.
• W4383998082 cites W2114445825 @default.
• W4383998082 cites W2130591775 @default.
• W4383998082 cites W2135919238 @default.
• W4383998082 cites W2139021684 @default.
• W4383998082 cites W2157942810 @default.
• W4383998082 cites W2285911646 @default.
• W4383998082 cites W2563386262 @default.
• W4383998082 cites W2760866275 @default.
• W4383998082 cites W2767757592 @default.
• W4383998082 cites W2781907612 @default.
• W4383998082 cites W2792452770 @default.
• W4383998082 cites W2883606836 @default.
• W4383998082 cites W2898966194 @default.
• W4383998082 cites W2917549746 @default.
• W4383998082 cites W2921832099 @default.
• W4383998082 cites W2956374509 @default.
• W4383998082 cites W2965565646 @default.
• W4383998082 cites W2989639013 @default.
• W4383998082 cites W3005173199 @default.
• W4383998082 cites W3006337035 @default.
• W4383998082 cites W3010153035 @default.
• W4383998082 cites W3025324697 @default.
• W4383998082 cites W3117729869 @default.
• W4383998082 cites W3159553684 @default.
• W4383998082 cites W3196654697 @default.
• W4383998082 cites W3199764899 @default.
• W4383998082 cites W3205927533 @default.
• W4383998082 cites W3214783737 @default.
• W4383998082 cites W4214511313 @default.
• W4383998082 cites W4220689228 @default.
• W4383998082 cites W4220796025 @default.
• W4383998082 doi "https://doi.org/10.1002/tox.23878" @default.
• W4383998082 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37436145" @default.
• W4383998082 hasPublicationYear "2023" @default.
• W4383998082 type Work @default.
• W4383998082 citedByCount "0" @default.
• W4383998082 crossrefType "journal-article" @default.
• W4383998082 hasAuthorship W4383998082A5014556310 @default.
• W4383998082 hasAuthorship W4383998082A5014624359 @default.
• W4383998082 hasAuthorship W4383998082A5026362839 @default.
• W4383998082 hasAuthorship W4383998082A5037014628 @default.
• W4383998082 hasAuthorship W4383998082A5041753664 @default.
• W4383998082 hasAuthorship W4383998082A5065683417 @default.
• W4383998082 hasAuthorship W4383998082A5075874833 @default.
• W4383998082 hasAuthorship W4383998082A5076036497 @default.
• W4383998082 hasAuthorship W4383998082A5079237288 @default.
• W4383998082 hasAuthorship W4383998082A5083311955 @default.
• W4383998082 hasAuthorship W4383998082A5085908543 @default.
• W4383998082 hasConcept C104317684 @default.
• W4383998082 hasConcept C114246631 @default.
• W4383998082 hasConcept C127561419 @default.
• W4383998082 hasConcept C170493617 @default.
• W4383998082 hasConcept C185592680 @default.
• W4383998082 hasConcept C203014093 @default.
• W4383998082 hasConcept C2776070231 @default.
• W4383998082 hasConcept C2776536020 @default.
• W4383998082 hasConcept C2776914184 @default.
• W4383998082 hasConcept C2777538855 @default.
• W4383998082 hasConcept C2780545709 @default.
• W4383998082 hasConcept C55493867 @default.
• W4383998082 hasConcept C62478195 @default.
• W4383998082 hasConcept C86803240 @default.
• W4383998082 hasConcept C88045685 @default.
• W4383998082 hasConcept C95444343 @default.
• W4383998082 hasConcept C98274493 @default.
• W4383998082 hasConceptScore W4383998082C104317684 @default.
• W4383998082 hasConceptScore W4383998082C114246631 @default.
• W4383998082 hasConceptScore W4383998082C127561419 @default.
• W4383998082 hasConceptScore W4383998082C170493617 @default.
• W4383998082 hasConceptScore W4383998082C185592680 @default.
• W4383998082 hasConceptScore W4383998082C203014093 @default.
• W4383998082 hasConceptScore W4383998082C2776070231 @default.
• W4383998082 hasConceptScore W4383998082C2776536020 @default.
• W4383998082 hasConceptScore W4383998082C2776914184 @default.
• W4383998082 hasConceptScore W4383998082C2777538855 @default.
• W4383998082 hasConceptScore W4383998082C2780545709 @default.
• W4383998082 hasConceptScore W4383998082C55493867 @default.
• W4383998082 hasConceptScore W4383998082C62478195 @default.

• next