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• W4383998357 abstract "Psoriasis is a chronic inflammatory skin disorder. The mechanism of psoriasis pathogenesis is not entirely clear. Here, we reported that the level of the N6-methyladenosine (m6 A) modification was increased in psoriatic CD4+ T cells compared with healthy controls. In the psoriasis mouse model, depletion of the RNA demethylase, Alkbh5, from CD4+ T cells promoted the psoriasis-like phenotype and inflammation. Intriguingly, this phenotype and inflammation were alleviated by the ablation of the m6 A methyltransferase Mettl3 in CD4+ T cells. Mechanistically, we found that the m6 A modification of IL17A mRNA increased the expression of IL-17A (an important pro-inflammatory factor in psoriasis) and promoted psoriasis. Thus, our study provided evidence that the m6 A modification of IL17A in CD4+ T cells regulates inflammation in psoriasis." @default.
• W4383998357 created "2023-07-13" @default.
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• W4383998357 date "2023-07-12" @default.
• W4383998357 modified "2023-10-17" @default.
• W4383998357 title "The <scp>m⁶A</scp> modification of <i>Il17a</i> in <scp>CD4</scp>⁺ T cells promotes inflammation in psoriasis" @default.
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• W4383998357 doi "https://doi.org/10.1111/exd.14879" @default.
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