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- W4384008459 abstract "Translation is a crucial step in gene expression and plays a vital role in regulating various aspects of plant development and environmental responses. It is a dynamic and complex program that involves interactions between mRNAs, tRNAs, and the ribosome machinery, through both cis- and trans-regulation, while integrating internal and external signals. Translational control can act in a global (transcriptome-wide) or mRNA-specific manner. Recent advances in genome-wide techniques, particularly ribosome profiling and proteomics, have led to numerous exciting discoveries in both global and mRNA-specific translation. In this review, we aim to provide a 'primer' that introduces readers to this fascinating yet complex cellular process and provide a big picture of how essential components connect within the network. We begin with an overview of mRNA translation, followed by a discussion of the experimental approaches and recent findings in the field, focusing on unannotated translation events and translational control through cis-regulatory elements on mRNAs and trans-acting factors, as well as signaling networks through three conserved translational regulators TOR, SnRK1, and GCN2. Finally, we briefly touch on the spatial regulation of mRNAs in translational control. Here, we focus on cytosolic mRNAs, and translation in organelles and viruses is not covered in this review." @default.
- W4384008459 created "2023-07-13" @default.
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- W4384008459 date "2023-07-12" @default.
- W4384008459 modified "2023-09-30" @default.
- W4384008459 title "What, where, and how: Regulation of translation and the translational landscape in plants" @default.
- W4384008459 doi "https://doi.org/10.1093/plcell/koad197" @default.
- W4384008459 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37437121" @default.
- W4384008459 hasPublicationYear "2023" @default.
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