FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4384008977> ?p ?o ?g. }

• W4384008977 endingPage "200" @default.
• W4384008977 startingPage "192" @default.
• W4384008977 abstract "BackgroundVancomycin-resistant Enterococcus faecium (VRE) is a leading cause of nosocomial infection, driven by its ability to spread between patients and persist in the hospital environment. Here, we investigated the impact of a long-established cardiothoracic hospital moving to new premises with close to 100% single-occupancy rooms on the rates of environmental contamination and infection or colonisation by VRE.MethodProspective environmental surveillance for VRE was conducted at five time-points between April and November 2019, once in the original building, and four times in the new building. Flocked swabs (n=100/time-point) were used to sample bedspaces, bathrooms, computers and sluices in the critical care unit and the cardiothoracic ward. Environmental VRE was supplemented by clinical VRE isolates from the same time period, and underwent whole genome sequencing. Incidence rate ratios (IRR) of VRE infection/colonisation was determined for the one-year period before and after the hospital move, and compared to a nearby hospital.FindingsIn the original location, the first environmental screen found 29% VRE positivity. The following four screens in the new location showed a significant reduction in positivity (1-6%, p<0·0001). The VRE infection/colonisation rates were halved in the new location (IRR 0·56, 95% CI 0·38-0·84), compared to the original location, contrasting to an increase in a nearby hospital (IRR 1·62, 95% CI 1·17-2·27) over the same time period. Genomic analysis of the environmental isolates was consistent with reduced transmission in the new hospital.InterpretationThe use of single-occupancy rooms was associated with reduced environmental contamination with VRE, and lower transmission and isolation of VRE from clinical samples. The cost effectiveness of single-occupancy room hospitals in reducing healthcare-associated infections should be reassessed in the context of operational costs of emerging pandemic and increasing antimicrobial resistance threats.FundingThis publication presents independent research supported by the Health Innovation Challenge Fund (WT098600, HICF-T5-342), a parallel funding partnership between the Department of Health and Wellcome Trust. FC reports funding from the Wellcome Trust (LSHTM/Wellcome Institutional Strategic Support Fund Fellowship [204928/Z/16/Z]. KR was supported by an ESCMID Research Grant (ref. 15996)." @default.
• W4384008977 created "2023-07-13" @default.
• W4384008977 creator A5008249380 @default.
• W4384008977 creator A5010220954 @default.
• W4384008977 creator A5014626556 @default.
• W4384008977 creator A5026351567 @default.
• W4384008977 creator A5026999554 @default.
• W4384008977 creator A5046531377 @default.
• W4384008977 creator A5062750618 @default.
• W4384008977 creator A5069741248 @default.
• W4384008977 creator A5079123140 @default.
• W4384008977 date "2023-09-01" @default.
• W4384008977 modified "2023-09-27" @default.
• W4384008977 title "Impact of a new hospital with close to 100% single-occupancy rooms on environmental contamination and incidence of vancomycin-resistant Enterococcus faecium colonization or infection: a genomic surveillance study" @default.
• W4384008977 cites W1972145956 @default.
• W4384008977 cites W1988972143 @default.
• W4384008977 cites W1990152860 @default.
• W4384008977 cites W2002683729 @default.
• W4384008977 cites W2021463425 @default.
• W4384008977 cites W2096093282 @default.
• W4384008977 cites W2120902911 @default.
• W4384008977 cites W2124614881 @default.
• W4384008977 cites W2131818949 @default.
• W4384008977 cites W2133540866 @default.
• W4384008977 cites W2142554396 @default.
• W4384008977 cites W2154611004 @default.
• W4384008977 cites W2189133941 @default.
• W4384008977 cites W2513727910 @default.
• W4384008977 cites W2559301275 @default.
• W4384008977 cites W2576430068 @default.
• W4384008977 cites W2745352520 @default.
• W4384008977 cites W2771070148 @default.
• W4384008977 cites W2796097905 @default.
• W4384008977 cites W2799783145 @default.
• W4384008977 cites W2900048817 @default.
• W4384008977 cites W2915268657 @default.
• W4384008977 cites W2921622580 @default.
• W4384008977 cites W2921820590 @default.
• W4384008977 cites W2950006954 @default.
• W4384008977 cites W2969482320 @default.
• W4384008977 cites W3045244624 @default.
• W4384008977 cites W3093949786 @default.
• W4384008977 cites W3208764949 @default.
• W4384008977 cites W4206677002 @default.
• W4384008977 cites W4225882325 @default.
• W4384008977 doi "https://doi.org/10.1016/j.jhin.2023.06.025" @default.
• W4384008977 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37451408" @default.
• W4384008977 hasPublicationYear "2023" @default.
• W4384008977 type Work @default.
• W4384008977 citedByCount "0" @default.
• W4384008977 crossrefType "journal-article" @default.
• W4384008977 hasAuthorship W4384008977A5008249380 @default.
• W4384008977 hasAuthorship W4384008977A5010220954 @default.
• W4384008977 hasAuthorship W4384008977A5014626556 @default.
• W4384008977 hasAuthorship W4384008977A5026351567 @default.
• W4384008977 hasAuthorship W4384008977A5026999554 @default.
• W4384008977 hasAuthorship W4384008977A5046531377 @default.
• W4384008977 hasAuthorship W4384008977A5062750618 @default.
• W4384008977 hasAuthorship W4384008977A5069741248 @default.
• W4384008977 hasAuthorship W4384008977A5079123140 @default.
• W4384008977 hasBestOaLocation W43840089771 @default.
• W4384008977 hasConcept C105878827 @default.
• W4384008977 hasConcept C119599485 @default.
• W4384008977 hasConcept C120665830 @default.
• W4384008977 hasConcept C121332964 @default.
• W4384008977 hasConcept C127413603 @default.
• W4384008977 hasConcept C166888038 @default.
• W4384008977 hasConcept C177713679 @default.
• W4384008977 hasConcept C194828623 @default.
• W4384008977 hasConcept C2776927270 @default.
• W4384008977 hasConcept C2777490607 @default.
• W4384008977 hasConcept C2777677444 @default.
• W4384008977 hasConcept C2778980435 @default.
• W4384008977 hasConcept C2779489039 @default.
• W4384008977 hasConcept C2780585763 @default.
• W4384008977 hasConcept C2910137292 @default.
• W4384008977 hasConcept C42972112 @default.
• W4384008977 hasConcept C501593827 @default.
• W4384008977 hasConcept C523546767 @default.
• W4384008977 hasConcept C54355233 @default.
• W4384008977 hasConcept C61511704 @default.
• W4384008977 hasConcept C71924100 @default.
• W4384008977 hasConcept C761482 @default.
• W4384008977 hasConcept C86803240 @default.
• W4384008977 hasConcept C89423630 @default.
• W4384008977 hasConceptScore W4384008977C105878827 @default.
• W4384008977 hasConceptScore W4384008977C119599485 @default.
• W4384008977 hasConceptScore W4384008977C120665830 @default.
• W4384008977 hasConceptScore W4384008977C121332964 @default.
• W4384008977 hasConceptScore W4384008977C127413603 @default.
• W4384008977 hasConceptScore W4384008977C166888038 @default.
• W4384008977 hasConceptScore W4384008977C177713679 @default.
• W4384008977 hasConceptScore W4384008977C194828623 @default.
• W4384008977 hasConceptScore W4384008977C2776927270 @default.
• W4384008977 hasConceptScore W4384008977C2777490607 @default.
• W4384008977 hasConceptScore W4384008977C2777677444 @default.
• W4384008977 hasConceptScore W4384008977C2778980435 @default.
• W4384008977 hasConceptScore W4384008977C2779489039 @default.

• next