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- W4384023354 abstract "A practical strategy for thioester ligation using peptide hydrazides as crypto-thioesters is reported. In the convergent ligation strategy of thioester ligation, the N-terminal amino group of the intermediate thioester peptide readily reacts with its C-terminal thioester moiety via head-to-tail cyclisation. So far, peptide hydrazide has not yet been used as a crypto-thioester in thioester ligation because it reacts with thioesters in the presence of silver ion. To address this issue, we use di-tert-butyl dicarbonate to selectively protect the C-terminal acyl hydrazide under acidic conditions. The robustness and easy operability of this strategy will expand the utility of thioester ligation in chemical protein synthesis." @default.
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- W4384023354 date "2023-08-01" @default.
- W4384023354 modified "2023-10-14" @default.
- W4384023354 title "Thioester ligation using peptide hydrazides as crypto-thioesters" @default.
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- W4384023354 doi "https://doi.org/10.1016/j.tetlet.2023.154645" @default.
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