FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4384023786> ?p ?o ?g. }

• W4384023786 abstract "Abstract Dementia is common in Parkinson’s disease, but there is wide variation in its timing. With the emergence of disease modifying treatments in neurodegeneration, there is increasing need to detect and treat disease at the earliest stages and to monitor disease progression. A critical gap in Parkinson’s disease is the lack of quantifiable markers of progression, and methods to identify early stages. Until recently, MRI has had limited sensitivity to detect or track changes relating to Parkinson’s dementia, but advanced techniques, especially quantitative magnetic susceptibility mapping (QSM) which is sensitive to brain tissue iron, show potential for these purposes. So far, QSM, applied to cognition in Parkinson’s, has only been investigated in detail in cross-sectional cohorts. Here we present a longitudinal study throughout the brain using QSM in Parkinson’s disease. We included 59 Parkinson’s patients (with no dementia at study onset), and 22 controls, at baseline and after 3-year follow-up. Participants underwent detailed assessments of motor and cognitive severity at both timepoints. We found that increased magnetic susceptibility values in right temporal cortex and right putamen in patients were associated with poorer cognition at baseline. Strikingly, increased baseline susceptibility values within right temporal cortex, nucleus basalis of Meynert and putamen in patients were associated with greater cognitive severity after 3-year follow-up; and increased baseline susceptibility in basal ganglia, substantia nigra, red nucleus, insular cortex and dentate nucleus in patients were associated with greater motor severity after 3-year follow-up. We further found that after 3-years, increased follow-up susceptibility in these regions was associated with increased follow-up cognitive and motor severity, with further involvement of hippocampus relating to cognitive severity. However, region of interest analyses revealed that, in cortical regions, increases in paramagnetic susceptibility relating to iron could not alone explain the associations with increased clinical severity that were observed; and, similar to other studies, we did not find consistent increases in susceptibility within the 3-year follow-up period. Our study suggests that QSM has predictive sensitivity to detect changes in clinical severity many months prior to overt cognitive involvement in Parkinson’s. However, it also suggests that susceptibility within brain tissue over time may relate to changes in tissue composition other than iron concentration, such as in the relative proportion of myelin. Whilst our findings open the door for QSM to detect patients at the earliest stages of Parkinson’s dementia, we will require additional tissue metrics to augment the interpretation QSM, such that it can be used robustly in clinical practice or to provide outcome measures in therapeutic trials for disease modifying treatments in neurodegeneration." @default.
• W4384023786 created "2023-07-13" @default.
• W4384023786 creator A5001570471 @default.
• W4384023786 creator A5006887531 @default.
• W4384023786 creator A5062314534 @default.
• W4384023786 creator A5077718412 @default.
• W4384023786 creator A5088993021 @default.
• W4384023786 date "2023-07-12" @default.
• W4384023786 modified "2023-10-16" @default.
• W4384023786 title "Magnetic susceptibility is predictive of future clinical severity in Parkinson’s disease" @default.
• W4384023786 cites W1485368148 @default.
• W4384023786 cites W1498733903 @default.
• W4384023786 cites W1557133730 @default.
• W4384023786 cites W1762178123 @default.
• W4384023786 cites W1937648683 @default.
• W4384023786 cites W1964318214 @default.
• W4384023786 cites W1965514945 @default.
• W4384023786 cites W1981191197 @default.
• W4384023786 cites W1985613988 @default.
• W4384023786 cites W1986837796 @default.
• W4384023786 cites W1989070599 @default.
• W4384023786 cites W1989301646 @default.
• W4384023786 cites W2013854477 @default.
• W4384023786 cites W2034046047 @default.
• W4384023786 cites W2039852288 @default.
• W4384023786 cites W2058846847 @default.
• W4384023786 cites W2064939797 @default.
• W4384023786 cites W2071881327 @default.
• W4384023786 cites W2088634525 @default.
• W4384023786 cites W2110109740 @default.
• W4384023786 cites W2111388536 @default.
• W4384023786 cites W2117340355 @default.
• W4384023786 cites W2123913108 @default.
• W4384023786 cites W2126495520 @default.
• W4384023786 cites W2128017834 @default.
• W4384023786 cites W2134724878 @default.
• W4384023786 cites W2142470915 @default.
• W4384023786 cites W2150298956 @default.
• W4384023786 cites W2150821101 @default.
• W4384023786 cites W2176767889 @default.
• W4384023786 cites W2217420218 @default.
• W4384023786 cites W2258429837 @default.
• W4384023786 cites W2290257849 @default.
• W4384023786 cites W2336418363 @default.
• W4384023786 cites W2351832858 @default.
• W4384023786 cites W2416702677 @default.
• W4384023786 cites W2517121990 @default.
• W4384023786 cites W2518294556 @default.
• W4384023786 cites W2552765526 @default.
• W4384023786 cites W2567528101 @default.
• W4384023786 cites W2605236839 @default.
• W4384023786 cites W2605525681 @default.
• W4384023786 cites W2613273387 @default.
• W4384023786 cites W2751687247 @default.
• W4384023786 cites W2783729637 @default.
• W4384023786 cites W2792635754 @default.
• W4384023786 cites W2804998168 @default.
• W4384023786 cites W2808495410 @default.
• W4384023786 cites W2885110299 @default.
• W4384023786 cites W2888254910 @default.
• W4384023786 cites W2897698166 @default.
• W4384023786 cites W2899848855 @default.
• W4384023786 cites W2911622086 @default.
• W4384023786 cites W2914196409 @default.
• W4384023786 cites W2914965406 @default.
• W4384023786 cites W2944449430 @default.
• W4384023786 cites W2946627637 @default.
• W4384023786 cites W2952705709 @default.
• W4384023786 cites W2958270502 @default.
• W4384023786 cites W2974745094 @default.
• W4384023786 cites W3003960907 @default.
• W4384023786 cites W3008921454 @default.
• W4384023786 cites W3040655065 @default.
• W4384023786 cites W3088976177 @default.
• W4384023786 cites W3094011130 @default.
• W4384023786 cites W3118834564 @default.
• W4384023786 cites W3120643538 @default.
• W4384023786 cites W3122837568 @default.
• W4384023786 cites W3131532480 @default.
• W4384023786 cites W3134259195 @default.
• W4384023786 cites W3134940033 @default.
• W4384023786 cites W3137826907 @default.
• W4384023786 cites W3156055044 @default.
• W4384023786 cites W3160614385 @default.
• W4384023786 cites W3198938269 @default.
• W4384023786 cites W4220899186 @default.
• W4384023786 cites W4294237947 @default.
• W4384023786 cites W4295689620 @default.
• W4384023786 cites W4310461604 @default.
• W4384023786 cites W4318940675 @default.
• W4384023786 doi "https://doi.org/10.1101/2023.07.12.23292555" @default.
• W4384023786 hasPublicationYear "2023" @default.
• W4384023786 type Work @default.
• W4384023786 citedByCount "0" @default.
• W4384023786 crossrefType "posted-content" @default.
• W4384023786 hasAuthorship W4384023786A5001570471 @default.
• W4384023786 hasAuthorship W4384023786A5006887531 @default.
• W4384023786 hasAuthorship W4384023786A5062314534 @default.
• W4384023786 hasAuthorship W4384023786A5077718412 @default.
• W4384023786 hasAuthorship W4384023786A5088993021 @default.

• next