FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4384024650> ?p ?o ?g. }

• W4384024650 abstract "Abstract Evidence indicates that the microbiome plays a significant role in HIV immunopathogenesis and associated complications. This study aimed to characterize the oral and anal microbiome of Men who have Sex with Men (MSM) and Transgender Women (TGW), with and without HIV. One hundred and thirty oral and anal DNA-derived samples were obtained from 78 participants and subjected to shotgun metagenomics sequencing for further microbiome analysis. Significant differences in the microbiome composition were found among subjects associated with HIV infection, gender, sex behavior, CD4+ T-cell counts, antiretroviral therapy (ART), and the presence of HPV-associated precancerous anal lesions. Results confirm the occurrence of oncogenic viromes in this high HIV-risk population. The oral microbiome in HIV-associated cases exhibited an enrichment of bacteria associated with periodontal disease pathogenesis. Conversely, anal bacteria showed a significant decrease in HIV-infected subjects (Coprococcus comes, Finegoldia magna, Blautia obeum, Catenibacterium mitsuokai) . TGW showed enrichment in species related to sexual transmission, which concurs that most recruited TGW are or have been sex workers. Prevotella bivia and Fusobacterium gonidiaformans were positively associated with anal precancerous lesions among HIV-infected subjects. The enrichment of Holdemanella biformis and C. comes was associated with detectable viral load and ART-untreated patients. Metabolic pathways were distinctly affected by predominant factors linked to sexual behavior or HIV pathogenesis. Gene family analysis identified bacterial gene signatures as potential prognostic and predictive biomarkers for HIV/AIDS-associated malignancies. Conclusions: Identified microbial features at accessible sites are potential biomarkers for predicting precancerous anal lesions and therapeutic targets for HIV immunopathogenesis." @default.
• W4384024650 created "2023-07-13" @default.
• W4384024650 creator A5001100898 @default.
• W4384024650 creator A5008144660 @default.
• W4384024650 creator A5011852767 @default.
• W4384024650 creator A5036745399 @default.
• W4384024650 creator A5046556085 @default.
• W4384024650 creator A5059535797 @default.
• W4384024650 creator A5061001592 @default.
• W4384024650 creator A5061097917 @default.
• W4384024650 creator A5065603352 @default.
• W4384024650 creator A5069671423 @default.
• W4384024650 creator A5075873040 @default.
• W4384024650 date "2023-07-12" @default.
• W4384024650 modified "2023-10-09" @default.
• W4384024650 title "Oral and anal microbiome from HIV-exposed individuals: role of host-associated factors in taxa composition and metabolic pathways" @default.
• W4384024650 cites W1823200218 @default.
• W4384024650 cites W1969092579 @default.
• W4384024650 cites W1973661844 @default.
• W4384024650 cites W1974967716 @default.
• W4384024650 cites W1979409598 @default.
• W4384024650 cites W1994827009 @default.
• W4384024650 cites W2000293715 @default.
• W4384024650 cites W2002557186 @default.
• W4384024650 cites W2002795090 @default.
• W4384024650 cites W2003458325 @default.
• W4384024650 cites W2005708903 @default.
• W4384024650 cites W2005948802 @default.
• W4384024650 cites W2006713185 @default.
• W4384024650 cites W2014291489 @default.
• W4384024650 cites W2017045389 @default.
• W4384024650 cites W2033327108 @default.
• W4384024650 cites W2034189943 @default.
• W4384024650 cites W2036469855 @default.
• W4384024650 cites W2037505073 @default.
• W4384024650 cites W2056279562 @default.
• W4384024650 cites W2062677481 @default.
• W4384024650 cites W2102461176 @default.
• W4384024650 cites W2104602082 @default.
• W4384024650 cites W2109756901 @default.
• W4384024650 cites W2111358533 @default.
• W4384024650 cites W2113060243 @default.
• W4384024650 cites W2115046127 @default.
• W4384024650 cites W2117414599 @default.
• W4384024650 cites W2121748291 @default.
• W4384024650 cites W2122354899 @default.
• W4384024650 cites W2128601422 @default.
• W4384024650 cites W2132113202 @default.
• W4384024650 cites W2147825765 @default.
• W4384024650 cites W2149668969 @default.
• W4384024650 cites W2159482845 @default.
• W4384024650 cites W2167913729 @default.
• W4384024650 cites W2271249372 @default.
• W4384024650 cites W2297625970 @default.
• W4384024650 cites W2337536067 @default.
• W4384024650 cites W2520876614 @default.
• W4384024650 cites W2530301912 @default.
• W4384024650 cites W2531573051 @default.
• W4384024650 cites W2546959673 @default.
• W4384024650 cites W2548957578 @default.
• W4384024650 cites W2558204950 @default.
• W4384024650 cites W2572467248 @default.
• W4384024650 cites W2595070481 @default.
• W4384024650 cites W2749420302 @default.
• W4384024650 cites W2754077341 @default.
• W4384024650 cites W2764102310 @default.
• W4384024650 cites W2769206492 @default.
• W4384024650 cites W2769664962 @default.
• W4384024650 cites W2769753410 @default.
• W4384024650 cites W2772571049 @default.
• W4384024650 cites W2780443557 @default.
• W4384024650 cites W2784439478 @default.
• W4384024650 cites W2809715167 @default.
• W4384024650 cites W2888880494 @default.
• W4384024650 cites W2900697674 @default.
• W4384024650 cites W2945318499 @default.
• W4384024650 cites W2947036477 @default.
• W4384024650 cites W2951743813 @default.
• W4384024650 cites W2952276256 @default.
• W4384024650 cites W2969443468 @default.
• W4384024650 cites W2972734154 @default.
• W4384024650 cites W2975690531 @default.
• W4384024650 cites W2981792762 @default.
• W4384024650 cites W2990732901 @default.
• W4384024650 cites W2997579351 @default.
• W4384024650 cites W2998859113 @default.
• W4384024650 cites W3004123393 @default.
• W4384024650 cites W3006462474 @default.
• W4384024650 cites W3009022706 @default.
• W4384024650 cites W3009418082 @default.
• W4384024650 cites W3014418145 @default.
• W4384024650 cites W3023840458 @default.
• W4384024650 cites W3025149289 @default.
• W4384024650 cites W3034084432 @default.
• W4384024650 cites W3035423941 @default.
• W4384024650 cites W3047297170 @default.
• W4384024650 cites W3084956467 @default.
• W4384024650 cites W3121097551 @default.
• W4384024650 cites W3126814433 @default.
• W4384024650 cites W3154206657 @default.

• next