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• W4384025191 abstract "Diaphragm atrophy is a common side effect of mechanical ventilation and results in prolonged weaning. Electric phrenic nerve stimulation presents a possibility to avoid diaphragm atrophy by keeping the diaphragm conditioned in sedated patients. There is a need of further investigation on how to set stimulation parameters to achieve sufficient ventilation. A prototype system is presented with a systematic evaluation for stimulation pattern adjustments. The main indicator for efficient stimulation was the tidal volume. The evaluation was performed in two pig models. As a major finding, the results for biphasic pulses were more consistent than for alternating pulses. The tidal volume increased for a range of pulse frequency and pulse width until reaching a plateau at 80-120 Hz and 0.15 ms. Furthermore, the generated tidal volume and the stimulation pulse frequency were significantly correlated (0.42-0.84, [Formula: see text]). The results show which stimulation parameter combinations generate the highest tidal volume. We established a guideline on how to set stimulation parameters. The guideline is helpful for future clinical applications of phrenic nerve stimulation." @default.
• W4384025191 created "2023-07-13" @default.
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• W4384025191 date "2023-07-12" @default.
• W4384025191 modified "2023-10-06" @default.
• W4384025191 title "Evaluation of electric phrenic nerve stimulation patterns for mechanical ventilation: a pilot study" @default.
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• W4384025191 doi "https://doi.org/10.1038/s41598-023-38316-1" @default.
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