Matches in SemOpenAlex for { <https://semopenalex.org/work/W4384027573> ?p ?o ?g. }
- W4384027573 abstract "Developing tissues form spatial patterns by establishing concentration gradients of diffusible signaling proteins called morphogens. The bone morphogenetic protein (BMP) morphogen pathway uses a family of extracellular modulators to reshape signaling gradients by actively “shuttling” ligands to different locations. It has remained unclear what circuits are sufficient to enable shuttling, what other patterns they can generate, and whether shuttling is evolutionarily conserved. Here, using a synthetic, bottom-up approach, we compared the spatiotemporal dynamics of different extracellular circuits. Three proteins—Chordin, Twsg, and the BMP-1 protease—successfully displaced gradients by shuttling ligands away from the site of production. A mathematical model explained the different spatial dynamics of this and other circuits. Last, combining mammalian and Drosophila components in the same system suggests that shuttling is a conserved capability. Together, these results reveal principles through which extracellular circuits control the spatiotemporal dynamics of morphogen signaling." @default.
- W4384027573 created "2023-07-13" @default.
- W4384027573 creator A5003667239 @default.
- W4384027573 creator A5011450512 @default.
- W4384027573 creator A5034545266 @default.
- W4384027573 creator A5044049560 @default.
- W4384027573 creator A5063267847 @default.
- W4384027573 creator A5090684092 @default.
- W4384027573 date "2023-07-14" @default.
- W4384027573 modified "2023-09-26" @default.
- W4384027573 title "Reconstitution of morphogen shuttling circuits" @default.
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