FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4384029122> ?p ?o ?g. }

• W4384029122 endingPage "e067545" @default.
• W4384029122 startingPage "e067545" @default.
• W4384029122 abstract "Objective Despite the prevalence of osteoarthritis (OA) in England, few studies have examined the health economic impact of chronic pain associated with OA. The aim of this study was to compare outcomes in patients with moderate-to-severe chronic pain associated with OA and matched controls without known OA. Design Retrospective, longitudinal, observational cohort study. Setting Electronic records extracted from the Clinical Practice Research Datalink GOLD primary care database linked to Hospital Episode Statistics (HES) data set. Participants Patients (cases; n=5931) ≥18 years and with existing diagnosis of OA and moderate-to-severe pain associated with their OA, and controls matched on age, sex, comorbidity burden, general practitioner (GP) practice and availability of HES data. Interventions None. Primary and secondary outcome measures Total healthcare resource use (HCRU) and direct healthcare costs during 0–6, 0–12, 0–24 and 0–36 months of follow-up. Secondary outcomes measures included pharmacological management and time to total joint replacement. Results Patients with moderate-to-severe chronic pain associated with OA used significantly more healthcare services versus matched controls, reflected by higher HCRU and significantly higher direct costs. During the first 12 months’ follow-up, cases had significantly more GP consultations, outpatient attendances, emergency department visits and inpatient stays than matched controls (all p<0.0001). Total mean costs incurred by cases during 0–12 months’ follow-up were five times higher in cases versus controls (mean (SD): £4199 (£3966) vs £781 (£2073), respectively). Extensive cycling through pharmacological therapies was observed; among cases, 2040 (34.4%), 1340 (22.6%), 841 (14.2%), 459 (7.7%) and 706 (11.9%) received 1–5, 6–10, 11–15, 16–20 and >20 lines of therapy, respectively. Conclusions This wide-ranging, longitudinal, observational study of real-world primary and secondary care data demonstrates the impact of moderate-to-severe chronic pain associated with OA in patients compared with matched controls. Further studies are required to fully quantify the health economic burden of moderate-to-severe pain associated with OA." @default.
• W4384029122 created "2023-07-13" @default.
• W4384029122 creator A5003031084 @default.
• W4384029122 creator A5008585038 @default.
• W4384029122 creator A5009187197 @default.
• W4384029122 creator A5012998758 @default.
• W4384029122 creator A5014720616 @default.
• W4384029122 creator A5020186225 @default.
• W4384029122 creator A5034800401 @default.
• W4384029122 creator A5067014997 @default.
• W4384029122 creator A5068433429 @default.
• W4384029122 date "2023-07-01" @default.
• W4384029122 modified "2023-09-27" @default.
• W4384029122 title "Health economic impact of moderate-to-severe chronic pain associated with osteoarthritis in England: a retrospective analysis of linked primary and secondary care data" @default.
• W4384029122 cites W2007281313 @default.
• W4384029122 cites W2114128492 @default.
• W4384029122 cites W2119852447 @default.
• W4384029122 cites W2121797973 @default.
• W4384029122 cites W2153012086 @default.
• W4384029122 cites W2153434255 @default.
• W4384029122 cites W2162941809 @default.
• W4384029122 cites W2325025058 @default.
• W4384029122 cites W2543770221 @default.
• W4384029122 cites W2600525865 @default.
• W4384029122 cites W2924513576 @default.
• W4384029122 cites W2953735764 @default.
• W4384029122 cites W2969855692 @default.
• W4384029122 cites W3011510658 @default.
• W4384029122 cites W3083445186 @default.
• W4384029122 cites W3172107991 @default.
• W4384029122 cites W3176968173 @default.
• W4384029122 cites W3184004137 @default.
• W4384029122 cites W4205670898 @default.
• W4384029122 doi "https://doi.org/10.1136/bmjopen-2022-067545" @default.
• W4384029122 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37438077" @default.
• W4384029122 hasPublicationYear "2023" @default.
• W4384029122 type Work @default.
• W4384029122 citedByCount "0" @default.
• W4384029122 crossrefType "journal-article" @default.
• W4384029122 hasAuthorship W4384029122A5003031084 @default.
• W4384029122 hasAuthorship W4384029122A5008585038 @default.
• W4384029122 hasAuthorship W4384029122A5009187197 @default.
• W4384029122 hasAuthorship W4384029122A5012998758 @default.
• W4384029122 hasAuthorship W4384029122A5014720616 @default.
• W4384029122 hasAuthorship W4384029122A5020186225 @default.
• W4384029122 hasAuthorship W4384029122A5034800401 @default.
• W4384029122 hasAuthorship W4384029122A5067014997 @default.
• W4384029122 hasAuthorship W4384029122A5068433429 @default.
• W4384029122 hasBestOaLocation W43840291221 @default.
• W4384029122 hasConcept C107130276 @default.
• W4384029122 hasConcept C118552586 @default.
• W4384029122 hasConcept C121955636 @default.
• W4384029122 hasConcept C126322002 @default.
• W4384029122 hasConcept C142724271 @default.
• W4384029122 hasConcept C144133560 @default.
• W4384029122 hasConcept C160735492 @default.
• W4384029122 hasConcept C162324750 @default.
• W4384029122 hasConcept C167135981 @default.
• W4384029122 hasConcept C1862650 @default.
• W4384029122 hasConcept C194828623 @default.
• W4384029122 hasConcept C201903717 @default.
• W4384029122 hasConcept C204787440 @default.
• W4384029122 hasConcept C23131810 @default.
• W4384029122 hasConcept C27415008 @default.
• W4384029122 hasConcept C2776164576 @default.
• W4384029122 hasConcept C2779159551 @default.
• W4384029122 hasConcept C2780724011 @default.
• W4384029122 hasConcept C2781118164 @default.
• W4384029122 hasConcept C50522688 @default.
• W4384029122 hasConcept C6964187 @default.
• W4384029122 hasConcept C71924100 @default.
• W4384029122 hasConcept C72563966 @default.
• W4384029122 hasConceptScore W4384029122C107130276 @default.
• W4384029122 hasConceptScore W4384029122C118552586 @default.
• W4384029122 hasConceptScore W4384029122C121955636 @default.
• W4384029122 hasConceptScore W4384029122C126322002 @default.
• W4384029122 hasConceptScore W4384029122C142724271 @default.
• W4384029122 hasConceptScore W4384029122C144133560 @default.
• W4384029122 hasConceptScore W4384029122C160735492 @default.
• W4384029122 hasConceptScore W4384029122C162324750 @default.
• W4384029122 hasConceptScore W4384029122C167135981 @default.
• W4384029122 hasConceptScore W4384029122C1862650 @default.
• W4384029122 hasConceptScore W4384029122C194828623 @default.
• W4384029122 hasConceptScore W4384029122C201903717 @default.
• W4384029122 hasConceptScore W4384029122C204787440 @default.
• W4384029122 hasConceptScore W4384029122C23131810 @default.
• W4384029122 hasConceptScore W4384029122C27415008 @default.
• W4384029122 hasConceptScore W4384029122C2776164576 @default.
• W4384029122 hasConceptScore W4384029122C2779159551 @default.
• W4384029122 hasConceptScore W4384029122C2780724011 @default.
• W4384029122 hasConceptScore W4384029122C2781118164 @default.
• W4384029122 hasConceptScore W4384029122C50522688 @default.
• W4384029122 hasConceptScore W4384029122C6964187 @default.
• W4384029122 hasConceptScore W4384029122C71924100 @default.
• W4384029122 hasConceptScore W4384029122C72563966 @default.
• W4384029122 hasFunder F4320332759 @default.
• W4384029122 hasIssue "7" @default.
• W4384029122 hasLocation W43840291221 @default.

• next