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- W4384037342 endingPage "1428" @default.
- W4384037342 startingPage "1428" @default.
- W4384037342 abstract "Cilia are microtubule-based organelles that project from the cell surface with motility or sensory functions. Primary cilia work as antennae to sense and transduce extracellular signals. Cilia critically control proliferation by mediating cell-extrinsic signals and by regulating cell cycle entry. Recent studies have shown that primary cilia and their associated proteins also function in autophagy and genome stability, which are important players in oncogenesis. Abnormal functions of primary cilia may contribute to oncogenesis. Indeed, defective cilia can either promote or suppress cancers, depending on the cancer-initiating mutation, and the presence or absence of primary cilia is associated with specific cancer types. Together, these findings suggest that primary cilia play important, but distinct roles in different cancer types, opening up a completely new avenue of research to understand the biology and treatment of cancers. In this review, we discuss the roles of primary cilia in promoting or inhibiting oncogenesis based on the known or predicted functions of cilia and cilia-associated proteins in several key processes and related clinical implications." @default.
- W4384037342 created "2023-07-13" @default.
- W4384037342 creator A5039004318 @default.
- W4384037342 creator A5065588347 @default.
- W4384037342 creator A5081955195 @default.
- W4384037342 date "2023-07-11" @default.
- W4384037342 modified "2023-09-26" @default.
- W4384037342 title "Cilia and Cancer: From Molecular Genetics to Therapeutic Strategies" @default.
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