Matches in SemOpenAlex for { <https://semopenalex.org/work/W4384039134> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W4384039134 abstract "Abstract Fe II /α-ketoglutarate-dependent dioxygenases (Fe/αKG) are a large enzyme family that functionalize C-H bonds on diverse organic substrates. Although Fe/αKG homologs catalyze an array of chemically useful reactions, hydroxylation typically predominates. Microalgal DabC uniquely forms a novel C-C bond to construct the bioactive pyrrolidine ring in domoic acid biosynthesis. However, this kainoid synthase exclusively performs a stereospecific hydroxylation reaction on its cis substrate regioisomer. Mechanistic and kinetic analyses with native and alternative substrates identified a 20-fold rate increase in DabC radical cyclization over β–hydroxylation, with no observable 1,5-hydrogen atom transfer. Moreover, this dual activity was conserved among macroalgal RadC1 and KabC homologs and provided insight into substrate recognition and reactivity trends. Investigation of this substrate-dependent chemistry improves our understanding of Fe/αKG enzymes and their biocatalytic application." @default.
- W4384039134 created "2023-07-13" @default.
- W4384039134 creator A5055722604 @default.
- W4384039134 creator A5072919164 @default.
- W4384039134 date "2023-07-11" @default.
- W4384039134 modified "2023-09-25" @default.
- W4384039134 title "Algal kainoid synthases exhibit substrate-dependent hydroxylation and cyclization activities" @default.
- W4384039134 cites W1830282417 @default.
- W4384039134 cites W1976161451 @default.
- W4384039134 cites W2095752553 @default.
- W4384039134 cites W2122660082 @default.
- W4384039134 cites W2128586767 @default.
- W4384039134 cites W2170713825 @default.
- W4384039134 cites W2522493641 @default.
- W4384039134 cites W2562468815 @default.
- W4384039134 cites W2781612388 @default.
- W4384039134 cites W2786582492 @default.
- W4384039134 cites W2800193746 @default.
- W4384039134 cites W2809075674 @default.
- W4384039134 cites W2892867310 @default.
- W4384039134 cites W2904871827 @default.
- W4384039134 cites W2975312310 @default.
- W4384039134 cites W2985909004 @default.
- W4384039134 cites W3013598651 @default.
- W4384039134 cites W3048427487 @default.
- W4384039134 cites W3115365491 @default.
- W4384039134 cites W3169791506 @default.
- W4384039134 cites W3193616074 @default.
- W4384039134 cites W3211315663 @default.
- W4384039134 cites W4200403404 @default.
- W4384039134 cites W4210423784 @default.
- W4384039134 cites W4254394762 @default.
- W4384039134 cites W4280570348 @default.
- W4384039134 cites W4309368385 @default.
- W4384039134 cites W4319080496 @default.
- W4384039134 cites W4324027506 @default.
- W4384039134 cites W4361002383 @default.
- W4384039134 cites W4380488633 @default.
- W4384039134 doi "https://doi.org/10.1101/2023.07.10.548461" @default.
- W4384039134 hasPublicationYear "2023" @default.
- W4384039134 type Work @default.
- W4384039134 citedByCount "0" @default.
- W4384039134 crossrefType "posted-content" @default.
- W4384039134 hasAuthorship W4384039134A5055722604 @default.
- W4384039134 hasAuthorship W4384039134A5072919164 @default.
- W4384039134 hasBestOaLocation W43840391341 @default.
- W4384039134 hasConcept C112887158 @default.
- W4384039134 hasConcept C161790260 @default.
- W4384039134 hasConcept C178790620 @default.
- W4384039134 hasConcept C181199279 @default.
- W4384039134 hasConcept C185592680 @default.
- W4384039134 hasConcept C187921627 @default.
- W4384039134 hasConcept C18903297 @default.
- W4384039134 hasConcept C2777289219 @default.
- W4384039134 hasConcept C2781109383 @default.
- W4384039134 hasConcept C32909587 @default.
- W4384039134 hasConcept C71240020 @default.
- W4384039134 hasConcept C86803240 @default.
- W4384039134 hasConceptScore W4384039134C112887158 @default.
- W4384039134 hasConceptScore W4384039134C161790260 @default.
- W4384039134 hasConceptScore W4384039134C178790620 @default.
- W4384039134 hasConceptScore W4384039134C181199279 @default.
- W4384039134 hasConceptScore W4384039134C185592680 @default.
- W4384039134 hasConceptScore W4384039134C187921627 @default.
- W4384039134 hasConceptScore W4384039134C18903297 @default.
- W4384039134 hasConceptScore W4384039134C2777289219 @default.
- W4384039134 hasConceptScore W4384039134C2781109383 @default.
- W4384039134 hasConceptScore W4384039134C32909587 @default.
- W4384039134 hasConceptScore W4384039134C71240020 @default.
- W4384039134 hasConceptScore W4384039134C86803240 @default.
- W4384039134 hasLocation W43840391341 @default.
- W4384039134 hasOpenAccess W4384039134 @default.
- W4384039134 hasPrimaryLocation W43840391341 @default.
- W4384039134 hasRelatedWork W1969243791 @default.
- W4384039134 hasRelatedWork W1972580032 @default.
- W4384039134 hasRelatedWork W1999282026 @default.
- W4384039134 hasRelatedWork W2012747950 @default.
- W4384039134 hasRelatedWork W2033694893 @default.
- W4384039134 hasRelatedWork W2151012017 @default.
- W4384039134 hasRelatedWork W2439449588 @default.
- W4384039134 hasRelatedWork W2950655684 @default.
- W4384039134 hasRelatedWork W4245595161 @default.
- W4384039134 hasRelatedWork W4313463203 @default.
- W4384039134 isParatext "false" @default.
- W4384039134 isRetracted "false" @default.
- W4384039134 workType "article" @default.