FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4384039662> ?p ?o ?g. }

• W4384039662 endingPage "165461" @default.
• W4384039662 startingPage "165461" @default.
• W4384039662 abstract "The production of plastics worldwide has been instrumental in the progress of modern society, while the increasing accumulation of plastics castoff in oceans, soils and anywhere else has become a major pressure source on environmental sustainability and animal health. Meanwhile, from a biological perspective, our understanding of the toxicological fingerprints of plastics, especially microplastics (MPs), is still poor. Here, we reported a phenomenon of hepatotoxicity dominated by MPs in the form of polystyrene (PS), was observed in mice model systems and cellular assays. Apoptosis and necroptosis related to the size of particles were seen upon PS-MPs introduction, as revealed by transmission electron microscopy, fluorescence microscopy, flow cytometry, and quantitative analysis of signaling pathways in vivo and vitro. Collectively, the current study demonstrated that the levels of liver cell injury caused by PS-MPs were negatively correlated with the particle diameters. Small-sized particles (1-10 μm) induced cell death primarily as necroptosis whereas the large-sized particles (50-100 μm) mainly induced apoptosis, which was directly accomplished by PTEN/PI3K/AKT signaling axis and its targeted autophagy flux. More interestingly, inhibition of autophagy not only alleviated PS-MPs-triggered cell death, but also changed the form of death injury to a certain extent. This uncovered crosstalk relationship opens up a new avenue for investigating the biological and toxicological effects of MPs, and may provide important insights for preventing and limiting of health hazards from MPs." @default.
• W4384039662 created "2023-07-13" @default.
• W4384039662 creator A5018861641 @default.
• W4384039662 creator A5042025490 @default.
• W4384039662 creator A5050717127 @default.
• W4384039662 creator A5055114063 @default.
• W4384039662 creator A5089383446 @default.
• W4384039662 date "2023-11-01" @default.
• W4384039662 modified "2023-10-14" @default.
• W4384039662 title "Polystyrene microplastics with different sizes induce the apoptosis and necroptosis in liver through the PTEN/PI3K/AKT/autophagy axis" @default.
• W4384039662 cites W1994302475 @default.
• W4384039662 cites W2003022112 @default.
• W4384039662 cites W2109882045 @default.
• W4384039662 cites W2166616170 @default.
• W4384039662 cites W2601166832 @default.
• W4384039662 cites W2620099204 @default.
• W4384039662 cites W2742372030 @default.
• W4384039662 cites W2791508589 @default.
• W4384039662 cites W2903763818 @default.
• W4384039662 cites W2913637697 @default.
• W4384039662 cites W2918895016 @default.
• W4384039662 cites W2957672988 @default.
• W4384039662 cites W2977747666 @default.
• W4384039662 cites W2996335527 @default.
• W4384039662 cites W3001899170 @default.
• W4384039662 cites W3005939696 @default.
• W4384039662 cites W3006859781 @default.
• W4384039662 cites W3007454643 @default.
• W4384039662 cites W3010709323 @default.
• W4384039662 cites W3017793098 @default.
• W4384039662 cites W3025390068 @default.
• W4384039662 cites W3027689559 @default.
• W4384039662 cites W3048318968 @default.
• W4384039662 cites W3090593801 @default.
• W4384039662 cites W3107320558 @default.
• W4384039662 cites W3126538505 @default.
• W4384039662 cites W3130946532 @default.
• W4384039662 cites W3155218848 @default.
• W4384039662 cites W3159219239 @default.
• W4384039662 cites W3171670357 @default.
• W4384039662 cites W3183927164 @default.
• W4384039662 cites W3193102422 @default.
• W4384039662 cites W3206433829 @default.
• W4384039662 cites W4205186972 @default.
• W4384039662 cites W4210875240 @default.
• W4384039662 cites W4211020476 @default.
• W4384039662 cites W4220733997 @default.
• W4384039662 cites W4221109576 @default.
• W4384039662 cites W4229366597 @default.
• W4384039662 cites W4283078112 @default.
• W4384039662 cites W4283836122 @default.
• W4384039662 cites W4285390636 @default.
• W4384039662 cites W4292868142 @default.
• W4384039662 cites W4293216450 @default.
• W4384039662 cites W4303418910 @default.
• W4384039662 cites W4323363054 @default.
• W4384039662 cites W4323652061 @default.
• W4384039662 doi "https://doi.org/10.1016/j.scitotenv.2023.165461" @default.
• W4384039662 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37451460" @default.
• W4384039662 hasPublicationYear "2023" @default.
• W4384039662 type Work @default.
• W4384039662 citedByCount "2" @default.
• W4384039662 countsByYear W43840396622023 @default.
• W4384039662 crossrefType "journal-article" @default.
• W4384039662 hasAuthorship W4384039662A5018861641 @default.
• W4384039662 hasAuthorship W4384039662A5042025490 @default.
• W4384039662 hasAuthorship W4384039662A5050717127 @default.
• W4384039662 hasAuthorship W4384039662A5055114063 @default.
• W4384039662 hasAuthorship W4384039662A5089383446 @default.
• W4384039662 hasConcept C185592680 @default.
• W4384039662 hasConcept C190283241 @default.
• W4384039662 hasConcept C203014093 @default.
• W4384039662 hasConcept C203522944 @default.
• W4384039662 hasConcept C2777609662 @default.
• W4384039662 hasConcept C2781000418 @default.
• W4384039662 hasConcept C31573885 @default.
• W4384039662 hasConcept C502942594 @default.
• W4384039662 hasConcept C553184892 @default.
• W4384039662 hasConcept C55493867 @default.
• W4384039662 hasConcept C75217442 @default.
• W4384039662 hasConcept C86554907 @default.
• W4384039662 hasConcept C86803240 @default.
• W4384039662 hasConcept C94030615 @default.
• W4384039662 hasConcept C95444343 @default.
• W4384039662 hasConceptScore W4384039662C185592680 @default.
• W4384039662 hasConceptScore W4384039662C190283241 @default.
• W4384039662 hasConceptScore W4384039662C203014093 @default.
• W4384039662 hasConceptScore W4384039662C203522944 @default.
• W4384039662 hasConceptScore W4384039662C2777609662 @default.
• W4384039662 hasConceptScore W4384039662C2781000418 @default.
• W4384039662 hasConceptScore W4384039662C31573885 @default.
• W4384039662 hasConceptScore W4384039662C502942594 @default.
• W4384039662 hasConceptScore W4384039662C553184892 @default.
• W4384039662 hasConceptScore W4384039662C55493867 @default.
• W4384039662 hasConceptScore W4384039662C75217442 @default.
• W4384039662 hasConceptScore W4384039662C86554907 @default.
• W4384039662 hasConceptScore W4384039662C86803240 @default.
• W4384039662 hasConceptScore W4384039662C94030615 @default.

• next