Matches in SemOpenAlex for { <https://semopenalex.org/work/W4384067495> ?p ?o ?g. }
- W4384067495 endingPage "11320" @default.
- W4384067495 startingPage "11320" @default.
- W4384067495 abstract "A water-soluble acacetin prodrug has been synthesized and reported by our group previously. Acetaminophen (APAP) overdose is a leading cause of acute liver injury. We found that subcutaneous injection of acacetin prodrug (5, 10, 20 mg/kg) decreased serum ALT, AST, and ALP, corrected the abnormal MDA and GSH in liver, and improved intrahepatic hemorrhage and destruction of liver structures in APAP (300 mg/kg)-treated mice. Molecular mechanism analysis revealed that the expressions of endoplasmic reticulum (ER) stress markers ATF6, CHOP, and p-PERK, apoptosis-related protein BAX, and cleaved caspase 3 were decreased by acacetin in a dose-dependent manner in vivo and in vitro. Moreover, via the acacetin-upregulated peroxisome-proliferator-activated receptor gamma (PPARγ) of HepG2 cells and liver, the suppressive effect of acacetin on ER stress and apoptosis was abolished by PPARγ inhibitor (GW9662) or PPARγ-siRNA. Molecular docking revealed that acacetin can bind to three active pockets of PPARγ, mainly by hydrogen bond. Our results provide novel evidence that acacetin prodrug exhibits significant protective effect against APAP-induced liver injury by targeting PPARγ, thereby suppressing ER stress and hepatocyte apoptosis. Acacetin prodrug is likely a promising new drug candidate for treating patients with acute liver injury induced by APAP." @default.
- W4384067495 created "2023-07-13" @default.
- W4384067495 creator A5001836351 @default.
- W4384067495 creator A5025180609 @default.
- W4384067495 creator A5029834763 @default.
- W4384067495 creator A5034275869 @default.
- W4384067495 creator A5044531468 @default.
- W4384067495 creator A5074516196 @default.
- W4384067495 creator A5077487584 @default.
- W4384067495 date "2023-07-11" @default.
- W4384067495 modified "2023-10-14" @default.
- W4384067495 title "Protective Effect of Water-Soluble Acacetin Prodrug on APAP-Induced Acute Liver Injury Is Associated with Upregulation of PPARγ and Alleviation of ER Stress" @default.
- W4384067495 cites W1902450517 @default.
- W4384067495 cites W1979020366 @default.
- W4384067495 cites W2002533466 @default.
- W4384067495 cites W2020888102 @default.
- W4384067495 cites W2021362373 @default.
- W4384067495 cites W2041220232 @default.
- W4384067495 cites W2042426013 @default.
- W4384067495 cites W2057505049 @default.
- W4384067495 cites W2060710455 @default.
- W4384067495 cites W2061763404 @default.
- W4384067495 cites W2068727603 @default.
- W4384067495 cites W2078036072 @default.
- W4384067495 cites W2081476839 @default.
- W4384067495 cites W2103591033 @default.
- W4384067495 cites W2125304341 @default.
- W4384067495 cites W2150256003 @default.
- W4384067495 cites W2333107025 @default.
- W4384067495 cites W2410690606 @default.
- W4384067495 cites W2461975652 @default.
- W4384067495 cites W2550126243 @default.
- W4384067495 cites W2552022555 @default.
- W4384067495 cites W2574920267 @default.
- W4384067495 cites W2593136873 @default.
- W4384067495 cites W2621670189 @default.
- W4384067495 cites W2737518257 @default.
- W4384067495 cites W2750981992 @default.
- W4384067495 cites W2786710826 @default.
- W4384067495 cites W2800988230 @default.
- W4384067495 cites W2810902309 @default.
- W4384067495 cites W2912062398 @default.
- W4384067495 cites W2942362005 @default.
- W4384067495 cites W2960902094 @default.
- W4384067495 cites W2974579689 @default.
- W4384067495 cites W2996669013 @default.
- W4384067495 cites W3011086993 @default.
- W4384067495 cites W3017434467 @default.
- W4384067495 cites W3082264053 @default.
- W4384067495 cites W3091819573 @default.
- W4384067495 cites W3195243551 @default.
- W4384067495 cites W3204825756 @default.
- W4384067495 cites W4200548651 @default.
- W4384067495 cites W4211193493 @default.
- W4384067495 cites W4281849152 @default.
- W4384067495 doi "https://doi.org/10.3390/ijms241411320" @default.
- W4384067495 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37511082" @default.
- W4384067495 hasPublicationYear "2023" @default.
- W4384067495 type Work @default.
- W4384067495 citedByCount "0" @default.
- W4384067495 crossrefType "journal-article" @default.
- W4384067495 hasAuthorship W4384067495A5001836351 @default.
- W4384067495 hasAuthorship W4384067495A5025180609 @default.
- W4384067495 hasAuthorship W4384067495A5029834763 @default.
- W4384067495 hasAuthorship W4384067495A5034275869 @default.
- W4384067495 hasAuthorship W4384067495A5044531468 @default.
- W4384067495 hasAuthorship W4384067495A5074516196 @default.
- W4384067495 hasAuthorship W4384067495A5077487584 @default.
- W4384067495 hasBestOaLocation W43840674951 @default.
- W4384067495 hasConcept C104317684 @default.
- W4384067495 hasConcept C108215921 @default.
- W4384067495 hasConcept C127561419 @default.
- W4384067495 hasConcept C139447449 @default.
- W4384067495 hasConcept C185592680 @default.
- W4384067495 hasConcept C190283241 @default.
- W4384067495 hasConcept C2776637226 @default.
- W4384067495 hasConcept C2777422422 @default.
- W4384067495 hasConcept C2778004101 @default.
- W4384067495 hasConcept C2778609962 @default.
- W4384067495 hasConcept C2778722691 @default.
- W4384067495 hasConcept C2778958039 @default.
- W4384067495 hasConcept C2779054382 @default.
- W4384067495 hasConcept C55493867 @default.
- W4384067495 hasConcept C71924100 @default.
- W4384067495 hasConcept C98274493 @default.
- W4384067495 hasConceptScore W4384067495C104317684 @default.
- W4384067495 hasConceptScore W4384067495C108215921 @default.
- W4384067495 hasConceptScore W4384067495C127561419 @default.
- W4384067495 hasConceptScore W4384067495C139447449 @default.
- W4384067495 hasConceptScore W4384067495C185592680 @default.
- W4384067495 hasConceptScore W4384067495C190283241 @default.
- W4384067495 hasConceptScore W4384067495C2776637226 @default.
- W4384067495 hasConceptScore W4384067495C2777422422 @default.
- W4384067495 hasConceptScore W4384067495C2778004101 @default.
- W4384067495 hasConceptScore W4384067495C2778609962 @default.
- W4384067495 hasConceptScore W4384067495C2778722691 @default.
- W4384067495 hasConceptScore W4384067495C2778958039 @default.
- W4384067495 hasConceptScore W4384067495C2779054382 @default.