Matches in SemOpenAlex for { <https://semopenalex.org/work/W4384068081> ?p ?o ?g. }
- W4384068081 abstract "Abstract Parkinson's disease is a devastating neurodegenerative disorder characterized by loss of neuromelanin‐containing dopaminergic neurons. Novel 3D culture systems like human midbrain‐like organoids (hMOs) enable new research avenues for patient‐specific therapies, but cannot reach their full potential unless rapid optical imaging of entire organoids is enabled. Currently, hMOs have to undergo tissue clearing processes before imaging to overcome light scattering. Since tissue clearing is a lengthy chemical procedure, large ensemble studies and pharmacological longitudinal studies, which require live cultures, are impossible. To address this obstacle, raster scanning optoacoustic mesoscopy (RSOM) is considered for imaging intact hMOs. RSOM is an optical imaging technique that leverages the optoacoustic effect to overcome the need of tissue clearing. Moreover, by using tomographic principles, large specimens can be imaged within minutes. The results confirm that RSOM can image the neuromelanin distribution in complete hMOs at a single‐cell resolution. Whole hMO volumes of standard size can be imaged in 4 min. Comparison with bright‐field microscopy and histology confirms the ground truth of the RSOM images. This work opens several research opportunities regarding neuromelanin in hMOs with potential to boost research in Parkinson disease." @default.
- W4384068081 created "2023-07-13" @default.
- W4384068081 creator A5014873628 @default.
- W4384068081 creator A5015300040 @default.
- W4384068081 creator A5020916455 @default.
- W4384068081 creator A5024517366 @default.
- W4384068081 creator A5025037879 @default.
- W4384068081 creator A5032932514 @default.
- W4384068081 creator A5059881887 @default.
- W4384068081 creator A5074791646 @default.
- W4384068081 date "2023-07-12" @default.
- W4384068081 modified "2023-10-18" @default.
- W4384068081 title "Fast 3D Optoacoustic Mesoscopy of Neuromelanin Through Entire Human Midbrain Organoids at Single‐Cell Resolution" @default.
- W4384068081 cites W1889609763 @default.
- W4384068081 cites W1987604126 @default.
- W4384068081 cites W1991092865 @default.
- W4384068081 cites W1993748326 @default.
- W4384068081 cites W2030964111 @default.
- W4384068081 cites W2031338189 @default.
- W4384068081 cites W2065462995 @default.
- W4384068081 cites W2067203318 @default.
- W4384068081 cites W2081644238 @default.
- W4384068081 cites W2092513871 @default.
- W4384068081 cites W2127939378 @default.
- W4384068081 cites W2490424988 @default.
- W4384068081 cites W2507172980 @default.
- W4384068081 cites W2612983876 @default.
- W4384068081 cites W2741520251 @default.
- W4384068081 cites W2779388899 @default.
- W4384068081 cites W2789460699 @default.
- W4384068081 cites W2900489664 @default.
- W4384068081 cites W2911952749 @default.
- W4384068081 cites W2917272302 @default.
- W4384068081 cites W2939711234 @default.
- W4384068081 cites W2957409313 @default.
- W4384068081 cites W2969821467 @default.
- W4384068081 cites W2986568526 @default.
- W4384068081 cites W3034174404 @default.
- W4384068081 cites W3111741012 @default.
- W4384068081 cites W3186137940 @default.
- W4384068081 cites W3186824561 @default.
- W4384068081 cites W3202904073 @default.
- W4384068081 cites W4211044101 @default.
- W4384068081 cites W4280567312 @default.
- W4384068081 doi "https://doi.org/10.1002/lpor.202300443" @default.
- W4384068081 hasPublicationYear "2023" @default.
- W4384068081 type Work @default.
- W4384068081 citedByCount "0" @default.
- W4384068081 crossrefType "journal-article" @default.
- W4384068081 hasAuthorship W4384068081A5014873628 @default.
- W4384068081 hasAuthorship W4384068081A5015300040 @default.
- W4384068081 hasAuthorship W4384068081A5020916455 @default.
- W4384068081 hasAuthorship W4384068081A5024517366 @default.
- W4384068081 hasAuthorship W4384068081A5025037879 @default.
- W4384068081 hasAuthorship W4384068081A5032932514 @default.
- W4384068081 hasAuthorship W4384068081A5059881887 @default.
- W4384068081 hasAuthorship W4384068081A5074791646 @default.
- W4384068081 hasBestOaLocation W43840680811 @default.
- W4384068081 hasConcept C136229726 @default.
- W4384068081 hasConcept C142724271 @default.
- W4384068081 hasConcept C169760540 @default.
- W4384068081 hasConcept C2779134260 @default.
- W4384068081 hasConcept C2779734285 @default.
- W4384068081 hasConcept C2780938664 @default.
- W4384068081 hasConcept C31695470 @default.
- W4384068081 hasConcept C41008148 @default.
- W4384068081 hasConcept C43310041 @default.
- W4384068081 hasConcept C71924100 @default.
- W4384068081 hasConcept C86803240 @default.
- W4384068081 hasConceptScore W4384068081C136229726 @default.
- W4384068081 hasConceptScore W4384068081C142724271 @default.
- W4384068081 hasConceptScore W4384068081C169760540 @default.
- W4384068081 hasConceptScore W4384068081C2779134260 @default.
- W4384068081 hasConceptScore W4384068081C2779734285 @default.
- W4384068081 hasConceptScore W4384068081C2780938664 @default.
- W4384068081 hasConceptScore W4384068081C31695470 @default.
- W4384068081 hasConceptScore W4384068081C41008148 @default.
- W4384068081 hasConceptScore W4384068081C43310041 @default.
- W4384068081 hasConceptScore W4384068081C71924100 @default.
- W4384068081 hasConceptScore W4384068081C86803240 @default.
- W4384068081 hasFunder F4320324195 @default.
- W4384068081 hasFunder F4320326644 @default.
- W4384068081 hasFunder F4320334506 @default.
- W4384068081 hasFunder F4320338335 @default.
- W4384068081 hasIssue "8" @default.
- W4384068081 hasLocation W43840680811 @default.
- W4384068081 hasOpenAccess W4384068081 @default.
- W4384068081 hasPrimaryLocation W43840680811 @default.
- W4384068081 hasRelatedWork W1558984540 @default.
- W4384068081 hasRelatedWork W1601438958 @default.
- W4384068081 hasRelatedWork W1966417657 @default.
- W4384068081 hasRelatedWork W2032587951 @default.
- W4384068081 hasRelatedWork W2076031180 @default.
- W4384068081 hasRelatedWork W2086361121 @default.
- W4384068081 hasRelatedWork W2144357875 @default.
- W4384068081 hasRelatedWork W2430360378 @default.
- W4384068081 hasRelatedWork W2516289434 @default.
- W4384068081 hasRelatedWork W2903786868 @default.
- W4384068081 hasVolume "17" @default.
- W4384068081 isParatext "false" @default.