FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4384068692> ?p ?o ?g. }

• W4384068692 abstract "Thyroid cancer (TC) is one of the fastest-growing malignant tumors. This study sought to explore the mechanism of immune escape mediated by receptor tyrosine kinase (KIT) in TC.The expression microarray of TC was acquired through the GEO database, and the difference analysis and Kyoto encyclopedia of genes and genomes pathway enrichment analysis were carried out. KIT levels in TC cell lines (K1/SW579/BCPAP) and human normal thyroid cells were detected using reverse transcription quantitative polymerase chain reaction and western blot analysis. TC cells were transfected with overexpressed (oe)-KIT and CD8+ T cells were cocultured with SW579 cells. Subsequently, cell proliferation, migration, and invasion abilities, CD8+ T cell proliferation, cytokine levels (interferon-γ [IFN-γ]/tumor necrosis factor-α [TNF-α]) were determined using colony formation assay, Transwell assays, flow cytometry, and enzyme-linked immunosorbent assay. The phosphorylation of MAPK pathway-related protein (ERK) was measured by western blot analysis. After transfection with oe-KIT, cells were treated with anisomycin (an activator of the MAPK pathway), and the protein levels of p-ERK/ERK and programmed death-ligand 1 (PD-L1) were detected.Differentially expressed genes (N = 2472) were obtained from the GEO database. KIT was reduced in TC samples and lower in tumor cells than those in normal cells. Overexpression of KIT inhibited immune escape of TC cells. Specifically, the proliferation, migration, and invasion abilities of TC cells were lowered, the proliferation level of CD8+ T cells was elevated, and IFN-γ and TNF-α levels were increased. KIT inhibited the activation of the MAPK pathway in TC cells and downregulated PD-L1.KIT suppressed immune escape of TC by blocking the activation of the MAPK pathway and downregulating PD-L1." @default.
• W4384068692 created "2023-07-13" @default.
• W4384068692 creator A5015888414 @default.
• W4384068692 creator A5021394088 @default.
• W4384068692 creator A5024054335 @default.
• W4384068692 creator A5031335804 @default.
• W4384068692 creator A5032769690 @default.
• W4384068692 creator A5062761052 @default.
• W4384068692 creator A5064622655 @default.
• W4384068692 creator A5068143834 @default.
• W4384068692 creator A5082409465 @default.
• W4384068692 creator A5084357635 @default.
• W4384068692 date "2023-07-01" @default.
• W4384068692 modified "2023-09-26" @default.
• W4384068692 title "Mechanism of immune escape mediated by receptor tyrosine kinase KIT in thyroid cancer" @default.
• W4384068692 cites W1810289459 @default.
• W4384068692 cites W1820831656 @default.
• W4384068692 cites W1869029218 @default.
• W4384068692 cites W1891905573 @default.
• W4384068692 cites W2017265537 @default.
• W4384068692 cites W2057443087 @default.
• W4384068692 cites W2069792474 @default.
• W4384068692 cites W2107773171 @default.
• W4384068692 cites W2177709689 @default.
• W4384068692 cites W2200937413 @default.
• W4384068692 cites W2398504502 @default.
• W4384068692 cites W2473996913 @default.
• W4384068692 cites W2595033379 @default.
• W4384068692 cites W2736470274 @default.
• W4384068692 cites W2760117061 @default.
• W4384068692 cites W2762784888 @default.
• W4384068692 cites W2790270315 @default.
• W4384068692 cites W2886414470 @default.
• W4384068692 cites W2902185751 @default.
• W4384068692 cites W2911909558 @default.
• W4384068692 cites W2922362422 @default.
• W4384068692 cites W2947298458 @default.
• W4384068692 cites W2953740547 @default.
• W4384068692 cites W2961221173 @default.
• W4384068692 cites W2980270483 @default.
• W4384068692 cites W2994852830 @default.
• W4384068692 cites W3007272780 @default.
• W4384068692 cites W3037210953 @default.
• W4384068692 cites W3041699323 @default.
• W4384068692 cites W3080952946 @default.
• W4384068692 cites W3085464158 @default.
• W4384068692 cites W3087616039 @default.
• W4384068692 cites W3092247655 @default.
• W4384068692 cites W3094583752 @default.
• W4384068692 cites W3128878077 @default.
• W4384068692 cites W3134878877 @default.
• W4384068692 cites W3141697761 @default.
• W4384068692 cites W3145181700 @default.
• W4384068692 cites W3204656681 @default.
• W4384068692 cites W4200625773 @default.
• W4384068692 cites W4210565002 @default.
• W4384068692 cites W4214749507 @default.
• W4384068692 cites W4214834751 @default.
• W4384068692 cites W4241749643 @default.
• W4384068692 doi "https://doi.org/10.1002/iid3.851" @default.
• W4384068692 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37506147" @default.
• W4384068692 hasPublicationYear "2023" @default.
• W4384068692 type Work @default.
• W4384068692 citedByCount "0" @default.
• W4384068692 crossrefType "journal-article" @default.
• W4384068692 hasAuthorship W4384068692A5015888414 @default.
• W4384068692 hasAuthorship W4384068692A5021394088 @default.
• W4384068692 hasAuthorship W4384068692A5024054335 @default.
• W4384068692 hasAuthorship W4384068692A5031335804 @default.
• W4384068692 hasAuthorship W4384068692A5032769690 @default.
• W4384068692 hasAuthorship W4384068692A5062761052 @default.
• W4384068692 hasAuthorship W4384068692A5064622655 @default.
• W4384068692 hasAuthorship W4384068692A5068143834 @default.
• W4384068692 hasAuthorship W4384068692A5082409465 @default.
• W4384068692 hasAuthorship W4384068692A5084357635 @default.
• W4384068692 hasBestOaLocation W43840686921 @default.
• W4384068692 hasConcept C153911025 @default.
• W4384068692 hasConcept C167672396 @default.
• W4384068692 hasConcept C17991360 @default.
• W4384068692 hasConcept C203014093 @default.
• W4384068692 hasConcept C502942594 @default.
• W4384068692 hasConcept C57074206 @default.
• W4384068692 hasConcept C62478195 @default.
• W4384068692 hasConcept C86803240 @default.
• W4384068692 hasConcept C8891405 @default.
• W4384068692 hasConcept C95444343 @default.
• W4384068692 hasConceptScore W4384068692C153911025 @default.
• W4384068692 hasConceptScore W4384068692C167672396 @default.
• W4384068692 hasConceptScore W4384068692C17991360 @default.
• W4384068692 hasConceptScore W4384068692C203014093 @default.
• W4384068692 hasConceptScore W4384068692C502942594 @default.
• W4384068692 hasConceptScore W4384068692C57074206 @default.
• W4384068692 hasConceptScore W4384068692C62478195 @default.
• W4384068692 hasConceptScore W4384068692C86803240 @default.
• W4384068692 hasConceptScore W4384068692C8891405 @default.
• W4384068692 hasConceptScore W4384068692C95444343 @default.
• W4384068692 hasIssue "7" @default.
• W4384068692 hasLocation W43840686921 @default.
• W4384068692 hasLocation W43840686922 @default.
• W4384068692 hasLocation W43840686923 @default.

• next