FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4384069868> ?p ?o ?g. }

• W4384069868 endingPage "125" @default.
• W4384069868 startingPage "117" @default.
• W4384069868 abstract "Introduction . Glioblastoma (GB) is not yet curable despite recent advances in the treatment of other malignant solid tumors. The management of GB is based solely on histopathological features, imaging of the tumor and its genomic analysis (somatic mutations in the isocitrate dehydrogenase genes, methylation status of the O 6 -methylguanine-DNA methyltransferase gene promoter). To adapt the treatment to the most recent tumor evolution, molecular information should be received regularly throughout the course of therapy. However, tumor tissue is often not available for diagnosis as the disease progresses. In this regard, the development of less invasive methods, such as analysis of the proteome of biological fluids of patients, is of particular interest. Cerebrospinal fluid (CSF) is an important source disease biomarkers to monitor the presence and progression of the disease. Aim . To identify proteomic predictive biomarkers in the CSF of patients with GB. Materials and methods . During the study, samples of patients’ CSF samples, high-resolution proteomic mass spectrometry, modern biochemical methods and bioinformatic technologies were used. Results . For the first time, the analysis of proteomes of CSF samples of patients with GB obtained before and 7 days after the removal of the primary tumor was carried out. Potential biomarkers of GB have been identified. After their validation using open databases, 11 proteomic predictive markers of GB (S100A9, S100A8, PLA2G15, PPIB, LTBP2, VIM, LAMB1, STC1, NRP1, COL6A1, HSPA5) were selected and their role in the molecular mechanisms of gliomagenesis was assessed. Conclusion. The proposed panel of proteomic predictive CSF biomarkers in GB patients can be further used in the development of test systems for assessing the effectiveness of therapy and early detection of disease relapses." @default.
• W4384069868 created "2023-07-13" @default.
• W4384069868 creator A5004618398 @default.
• W4384069868 creator A5009622308 @default.
• W4384069868 creator A5013007298 @default.
• W4384069868 creator A5017088706 @default.
• W4384069868 creator A5068491558 @default.
• W4384069868 creator A5091689051 @default.
• W4384069868 date "2023-07-10" @default.
• W4384069868 modified "2023-10-18" @default.
• W4384069868 title "Identification of predictive markers in the cerebrospinal fluid of patients with glioblastoma" @default.
• W4384069868 cites W2039793744 @default.
• W4384069868 cites W2054936631 @default.
• W4384069868 cites W2096287682 @default.
• W4384069868 cites W2109816625 @default.
• W4384069868 cites W2124143346 @default.
• W4384069868 cites W2126817554 @default.
• W4384069868 cites W2135236987 @default.
• W4384069868 cites W2145489645 @default.
• W4384069868 cites W2153450922 @default.
• W4384069868 cites W2219990356 @default.
• W4384069868 cites W2323456219 @default.
• W4384069868 cites W2511868181 @default.
• W4384069868 cites W2519691041 @default.
• W4384069868 cites W2732472098 @default.
• W4384069868 cites W2761714852 @default.
• W4384069868 cites W2795517864 @default.
• W4384069868 cites W2801403500 @default.
• W4384069868 cites W2808163099 @default.
• W4384069868 cites W2809914211 @default.
• W4384069868 cites W2892030326 @default.
• W4384069868 cites W2912196891 @default.
• W4384069868 cites W2918023653 @default.
• W4384069868 cites W2962976847 @default.
• W4384069868 cites W2968159162 @default.
• W4384069868 cites W2990710456 @default.
• W4384069868 cites W3006813113 @default.
• W4384069868 cites W3037508419 @default.
• W4384069868 cites W3110787789 @default.
• W4384069868 cites W3119238832 @default.
• W4384069868 cites W3137868593 @default.
• W4384069868 cites W3153827829 @default.
• W4384069868 cites W3161790216 @default.
• W4384069868 cites W3165532517 @default.
• W4384069868 cites W3215465622 @default.
• W4384069868 cites W4224111247 @default.
• W4384069868 cites W4224939755 @default.
• W4384069868 cites W4229008541 @default.
• W4384069868 cites W4289856856 @default.
• W4384069868 cites W4291134578 @default.
• W4384069868 cites W4293204247 @default.
• W4384069868 doi "https://doi.org/10.17650/2313-805x-2023-10-2-117-125" @default.
• W4384069868 hasPublicationYear "2023" @default.
• W4384069868 type Work @default.
• W4384069868 citedByCount "0" @default.
• W4384069868 crossrefType "journal-article" @default.
• W4384069868 hasAuthorship W4384069868A5004618398 @default.
• W4384069868 hasAuthorship W4384069868A5009622308 @default.
• W4384069868 hasAuthorship W4384069868A5013007298 @default.
• W4384069868 hasAuthorship W4384069868A5017088706 @default.
• W4384069868 hasAuthorship W4384069868A5068491558 @default.
• W4384069868 hasAuthorship W4384069868A5091689051 @default.
• W4384069868 hasBestOaLocation W43840698681 @default.
• W4384069868 hasConcept C104317684 @default.
• W4384069868 hasConcept C104397665 @default.
• W4384069868 hasConcept C121608353 @default.
• W4384069868 hasConcept C126322002 @default.
• W4384069868 hasConcept C142724271 @default.
• W4384069868 hasConcept C143998085 @default.
• W4384069868 hasConcept C181199279 @default.
• W4384069868 hasConcept C2777150147 @default.
• W4384069868 hasConcept C2779130545 @default.
• W4384069868 hasConcept C2779134260 @default.
• W4384069868 hasConcept C2779529041 @default.
• W4384069868 hasConcept C2779651940 @default.
• W4384069868 hasConcept C46111723 @default.
• W4384069868 hasConcept C502942594 @default.
• W4384069868 hasConcept C54355233 @default.
• W4384069868 hasConcept C55493867 @default.
• W4384069868 hasConcept C60644358 @default.
• W4384069868 hasConcept C71924100 @default.
• W4384069868 hasConcept C86803240 @default.
• W4384069868 hasConceptScore W4384069868C104317684 @default.
• W4384069868 hasConceptScore W4384069868C104397665 @default.
• W4384069868 hasConceptScore W4384069868C121608353 @default.
• W4384069868 hasConceptScore W4384069868C126322002 @default.
• W4384069868 hasConceptScore W4384069868C142724271 @default.
• W4384069868 hasConceptScore W4384069868C143998085 @default.
• W4384069868 hasConceptScore W4384069868C181199279 @default.
• W4384069868 hasConceptScore W4384069868C2777150147 @default.
• W4384069868 hasConceptScore W4384069868C2779130545 @default.
• W4384069868 hasConceptScore W4384069868C2779134260 @default.
• W4384069868 hasConceptScore W4384069868C2779529041 @default.
• W4384069868 hasConceptScore W4384069868C2779651940 @default.
• W4384069868 hasConceptScore W4384069868C46111723 @default.
• W4384069868 hasConceptScore W4384069868C502942594 @default.
• W4384069868 hasConceptScore W4384069868C54355233 @default.
• W4384069868 hasConceptScore W4384069868C55493867 @default.

• next