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- W4384070629 abstract "Abstract Nucleoid associated proteins (NAPs) maintain the architecture of bacterial chromosomes and regulate gene expression. Thus, their role as transcription factors may involve three-dimensional chromosome re-organisation. While this model is supported by in vitro studies, direct in vivo evidence is lacking. Here, we use RT-qPCR and 3C-qPCR to study the transcriptional and architectural profiles of the H-NS-regulated, osmoresponsive proVWX operon of Escherichia coli at different osmolarities and provide in vivo evidence for transcription regulation by NAP-mediated chromosome re-modelling in bacteria. We show that activation of proVWX in response to a hyperosmotic shock involves the destabilization of H-NS-mediated bridges anchored between the proVWX downstream and upstream regulatory elements (DRE and URE), and between the DRE and ygaY that lies immediately downstream of proVWX . The re-establishment of these bridges upon adaptation to hyperosmolarity represses the operon. H-NS and H-NS-like proteins are wide-spread amongst bacteria, suggesting that chromosome re-modelling may be a typical feature of transcriptional control in bacteria." @default.
- W4384070629 created "2023-07-13" @default.
- W4384070629 creator A5002777624 @default.
- W4384070629 creator A5024796305 @default.
- W4384070629 creator A5041471784 @default.
- W4384070629 creator A5069317982 @default.
- W4384070629 creator A5074521402 @default.
- W4384070629 creator A5088017596 @default.
- W4384070629 creator A5092454319 @default.
- W4384070629 date "2023-07-10" @default.
- W4384070629 modified "2023-09-27" @default.
- W4384070629 title "The environmentally-regulated interplay between local three-dimensional chromatin organisation and transcription of<i>proVWX</i>in<i>E. coli</i>" @default.
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