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- W4384071708 abstract "N6-methyladenosine (m6A), the most abundant mRNA modification, is deposited in mammals/insects/plants by m6A methyltransferase complexes (MTC) comprising a catalytic subunit and at least five additional proteins. The yeast MTC is critical for meiosis and was known to comprise three proteins, of which two were conserved. We uncover three novel MTC components (Kar4/Ygl036w-Vir1/Dyn2). All MTC subunits, except for Dyn2, are essential for m6A deposition and have corresponding mammalian MTC orthologs. Unlike the mammalian bipartite MTC, the yeast MTC is unipartite, yet multifunctional. The mRNA interacting module, comprising Ime4, Mum2, Vir1, and Kar4, exerts the MTC’s m6A-independent function, while Slz1 enables the MTC catalytic function in m6A deposition. Both functions are critical for meiotic progression. Kar4 also has a mechanistically separate role from the MTC during mating. The yeast MTC constituents play distinguishable m6A-dependent, MTC-dependent and MTC-independent functions, highlighting their complexity and paving the path towards dissecting multi-layered MTC functions in mammals." @default.
- W4384071708 created "2023-07-13" @default.
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- W4384071708 date "2023-07-12" @default.
- W4384071708 modified "2023-09-30" @default.
- W4384071708 title "The yeast RNA methylation complex consists of conserved yet reconfigured components with m6A-dependent and independent roles" @default.
- W4384071708 doi "https://doi.org/10.7554/elife.87860.2" @default.
- W4384071708 hasPublicationYear "2023" @default.
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