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- W4384108148 abstract "Abstract Background The induction of pyroptosis holds great promise as a strategy for improving the tumor immune microenvironment. Previous pyroptosis inducers have faced limitations, including drug resistance, toxic side effects, and a lack of targeting capabilities. As a result, there is a growing demand for tumor therapeutic molecules that can overcome these obstacles. With this in mind, the objective of this study is to develop a multifunctional nanospheres that addresses these challenges by enabling high-precision targeting of tumor cells and effective pyroptosis induction. Results We prepared a mannose-modified MOF called mannose-doped Fe 3 O 4 @NH 2 -MIL-100, referred to as M-FNM. M-FNM has the ability to enter CAL27 cells through MR-mediated endocytosis, which results in a significant increase in intracellular ROS levels. This increase subsequently triggers endoplasmic reticulum stress (ER stress) and activates the PERK-eIF2α-ATF4-CHOP signaling pathway. CHOP then mediates the downstream cascade of Caspase-1, inducing pyroptosis. In in vivo experiments, M-FNM demonstrates excellent targeting ability and exhibits anti-tumor effects. Additionally, M-FNM reshapes the immune microenvironment by promoting the infiltration of anti-tumor immune cells, primarily T lymphocytes. Conclusions M-FNM significantly decreased tumor growth. This novel approach of inducing pyroptosis in tumor cells using M-FNM may offer new avenues for the development of effective immunotherapies for cancer treatment." @default.
- W4384108148 created "2023-07-13" @default.
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- W4384108148 date "2023-07-12" @default.
- W4384108148 modified "2023-09-24" @default.
- W4384108148 title "Mannose-Doped Metal-Organic Frameworks Induce Tumor Cell Pyroptosis Via the PERK Pathway" @default.
- W4384108148 doi "https://doi.org/10.21203/rs.3.rs-3144329/v1" @default.
- W4384108148 hasPublicationYear "2023" @default.
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