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• W4384119701 abstract "Every organism is a model organism for understanding the development, evolution, disease, and regeneration, and we have only begun to scratch the surface of the interdisciplinary genetic, molecular, cellular, and developmental mechanisms that regulate these biological processes. These “Highlights” denote exciting advances recently reported in Developmental Dynamics that illustrate the complex dynamics of developmental biology. Cell Migration. “Singed and vinculin play redundant roles in cell migration by regulating F-actin” by Vandita Khaitan, Kinsuk Shill, Poulami Chatterjee, Sandipan Mukherjee, and Pralay Majumder; Dev Dyn 252:7, pp. 986–1008. https://doi.org/10.1002/dvdy.585. Cell migration is essential for organism development, adult homeostasis, and metastasis. This is particularly evident during Drosophila egg chamber morphogenesis in which border cells must navigate and migrate between nurse cells that are at the same time synthesizing nutrients for future egg development. This study examined the requirement for Singed and Vinculin in border cell migration, which is a highly dynamic process. Singed and vinculin were shown to genetically interact with each other to control F-actin within border cells and affect cell migration through the regulation of protrusion characteristics such as length, width, and direction. In addition to cell migration, synergy between Singed and Vinculin was observed in the brush border membrane and regulation of egg chamber shape. Genotype-Phenotype Correlation. “Discordant Growth of Nasal Cartilage and Bone Contributes to Phenotypic Variability of the Skull in a Mouse Model” by Shae Book, Alyssa Moore, Madeline Tourigny, Kevin Barr, and Katherine Willmore; Dev Dyn 252:7, pp. 1009–1025. https://doi.org/10.1002/dvdy.584. Genotype-phenotype correlation describes the relationship between a physical trait and a group of similar mutations. It can be informative for disease progression and pathogenesis but is dependent upon reliable genotyping and phenotyping. For structures that are developmentally complex such as the craniofacial skeleton, this can be challenging, since large differences in gene dosage often result in negligible phenotypic differences until a minimal threshold is surpassed. This study explores the function of the gap junctional protein Connexin 43 (CX43), mutations that are associated with oculodentodigital dysplasia and craniometaphysial dysplasia. Cx43 modulates skull shape variability in a nonlinear manner with threshold effects, illustrating that specific developmental processes contribute to the commonly observed nonlinear relationship between genotype and phenotype. Cilia and Cartilage Biology. “Zebrafish crocc2 mutants exhibit divergent craniofacial shape, misregulated variability, and aberrant cartilage morphogenesis” by Mary Packard, Michelle Gilbert, Emily Tetrault, and R. Craig Albertson; Dev Dyn 252:7, pp. 1026–1045. https://doi.org/10.1002/dvdy.591. Phenotypic variation is a fundamental property of development, evolution, and human health. However, the molecular mechanisms that influence variability are poorly understood. This study focused on crocc22, which encodes part of the rootlet of cilia, an antenna-like cellular organelle used to sense mechanical and biochemical stimuli and translate that information into biological signals inside a cell. Although “regulatory” genes are widely implicated in phenotypic variability, it is now clear that genes such as croc22 which encode “structural” parts of a cell are also major drivers of phenotypic variability." @default.
• W4384119701 created "2023-07-14" @default.
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• W4384119701 date "2023-07-01" @default.
• W4384119701 modified "2023-10-17" @default.
• W4384119701 title "Editorial highlights" @default.
• W4384119701 doi "https://doi.org/10.1002/dvdy.638" @default.
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