FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4384119741> ?p ?o ?g. }

• W4384119741 abstract "Abstract The superficial zone cells in mandibular condylar cartilage are proliferative. The present purpose was to delineate the relation of calcium‐sensing receptor (CaSR) and parathyroid hormone‐related peptide nuclear localization sequence (PTHrP 87‐139 ), and their role in the proliferation behaviors of the superficial zone cells. A gain‐ and loss‐of‐function strategy were used in an in vitro fluid flow shear stress (FFSS) model and an in vivo bilateral elevation bite model which showed mandibular condylar cartilage thickening. CaSR and PTHrP 87‐139 were modulated through treating the isolated superficial zone cells with activator/SiRNA and via deleting CaSR or parathyroid hormone‐related peptide (PTHrP) gene in mice with the promoter gene of proteoglycan 4 ( Prg4 ‐ Cre ERT2 ) in the tamoxifen‐inducible pattern with or without additional injection of Cinacalcet, the CaSR agonist, or PTHrP 87‐139 peptide. FFSS stimulated CaSR and PTHrP expression, and accelerated proliferation of the Prg4‐expressing superficial zone cells, in which process CaSR acted as an up‐streamer of PTHrP. Proteoglycan 4 specific knockout of CaSR or PTHrP reduced the cartilage thickness, suppressed the proliferation and early differentiation of the superficial zone cells, and inhibited cartilage thickening and matrix production promoted by bilateral elevation bite. Injections of CaSR agonist Cinacalcet could not improve the phenotype caused by PTHrP mutation. Injections of PTHrP 87‐139 peptide rescued the cartilage from knockout of CaSR gene. CaSR modulates proliferation of the superficial zone cells in mandibular condylar cartilage through activation of PTHrP nuclear localization sequence. Our data support the therapeutic target of CaSR in promoting PTHrP production in superficial zone cartilage." @default.
• W4384119741 created "2023-07-14" @default.
• W4384119741 creator A5001467702 @default.
• W4384119741 creator A5004441509 @default.
• W4384119741 creator A5024245752 @default.
• W4384119741 creator A5045816696 @default.
• W4384119741 creator A5046804972 @default.
• W4384119741 creator A5052282748 @default.
• W4384119741 creator A5053479474 @default.
• W4384119741 creator A5057136360 @default.
• W4384119741 creator A5059593844 @default.
• W4384119741 creator A5065763596 @default.
• W4384119741 creator A5090373795 @default.
• W4384119741 creator A5090519142 @default.
• W4384119741 date "2023-07-13" @default.
• W4384119741 modified "2023-10-09" @default.
• W4384119741 title "<scp>CaSR</scp> modulates proliferation of the superficial zone cells in temporomandibular joint cartilage via the <scp>PTHrP</scp> nuclear localization sequence" @default.
• W4384119741 cites W1980964476 @default.
• W4384119741 cites W1995499476 @default.
• W4384119741 cites W2009951650 @default.
• W4384119741 cites W2013268585 @default.
• W4384119741 cites W2017218776 @default.
• W4384119741 cites W2029049247 @default.
• W4384119741 cites W2041351247 @default.
• W4384119741 cites W2043232149 @default.
• W4384119741 cites W2062490687 @default.
• W4384119741 cites W2069705592 @default.
• W4384119741 cites W2076958216 @default.
• W4384119741 cites W2101702091 @default.
• W4384119741 cites W2116665554 @default.
• W4384119741 cites W2126202517 @default.
• W4384119741 cites W2140096924 @default.
• W4384119741 cites W2144246516 @default.
• W4384119741 cites W2168876853 @default.
• W4384119741 cites W2192198047 @default.
• W4384119741 cites W2213204018 @default.
• W4384119741 cites W2523393976 @default.
• W4384119741 cites W2565011576 @default.
• W4384119741 cites W2605778936 @default.
• W4384119741 cites W2762913705 @default.
• W4384119741 cites W2902169778 @default.
• W4384119741 cites W2912069300 @default.
• W4384119741 cites W2922998527 @default.
• W4384119741 cites W2947871968 @default.
• W4384119741 cites W3109780392 @default.
• W4384119741 cites W3134640361 @default.
• W4384119741 doi "https://doi.org/10.1096/fj.202300037rr" @default.
• W4384119741 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37440279" @default.
• W4384119741 hasPublicationYear "2023" @default.
• W4384119741 type Work @default.
• W4384119741 citedByCount "0" @default.
• W4384119741 crossrefType "journal-article" @default.
• W4384119741 hasAuthorship W4384119741A5001467702 @default.
• W4384119741 hasAuthorship W4384119741A5004441509 @default.
• W4384119741 hasAuthorship W4384119741A5024245752 @default.
• W4384119741 hasAuthorship W4384119741A5045816696 @default.
• W4384119741 hasAuthorship W4384119741A5046804972 @default.
• W4384119741 hasAuthorship W4384119741A5052282748 @default.
• W4384119741 hasAuthorship W4384119741A5053479474 @default.
• W4384119741 hasAuthorship W4384119741A5057136360 @default.
• W4384119741 hasAuthorship W4384119741A5059593844 @default.
• W4384119741 hasAuthorship W4384119741A5065763596 @default.
• W4384119741 hasAuthorship W4384119741A5090373795 @default.
• W4384119741 hasAuthorship W4384119741A5090519142 @default.
• W4384119741 hasBestOaLocation W43841197411 @default.
• W4384119741 hasConcept C105702510 @default.
• W4384119741 hasConcept C126322002 @default.
• W4384119741 hasConcept C134018914 @default.
• W4384119741 hasConcept C142590548 @default.
• W4384119741 hasConcept C170493617 @default.
• W4384119741 hasConcept C185592680 @default.
• W4384119741 hasConcept C2778828131 @default.
• W4384119741 hasConcept C2778938600 @default.
• W4384119741 hasConcept C2780550940 @default.
• W4384119741 hasConcept C2781208988 @default.
• W4384119741 hasConcept C519063684 @default.
• W4384119741 hasConcept C71924100 @default.
• W4384119741 hasConceptScore W4384119741C105702510 @default.
• W4384119741 hasConceptScore W4384119741C126322002 @default.
• W4384119741 hasConceptScore W4384119741C134018914 @default.
• W4384119741 hasConceptScore W4384119741C142590548 @default.
• W4384119741 hasConceptScore W4384119741C170493617 @default.
• W4384119741 hasConceptScore W4384119741C185592680 @default.
• W4384119741 hasConceptScore W4384119741C2778828131 @default.
• W4384119741 hasConceptScore W4384119741C2778938600 @default.
• W4384119741 hasConceptScore W4384119741C2780550940 @default.
• W4384119741 hasConceptScore W4384119741C2781208988 @default.
• W4384119741 hasConceptScore W4384119741C519063684 @default.
• W4384119741 hasConceptScore W4384119741C71924100 @default.
• W4384119741 hasFunder F4320321001 @default.
• W4384119741 hasIssue "8" @default.
• W4384119741 hasLocation W43841197411 @default.
• W4384119741 hasLocation W43841197412 @default.
• W4384119741 hasLocation W43841197413 @default.
• W4384119741 hasOpenAccess W4384119741 @default.
• W4384119741 hasPrimaryLocation W43841197411 @default.
• W4384119741 hasRelatedWork W1970114012 @default.
• W4384119741 hasRelatedWork W1976735578 @default.
• W4384119741 hasRelatedWork W1980321940 @default.
• W4384119741 hasRelatedWork W2027913950 @default.

• next