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- W4384120112 abstract "Retinitis pigmentosa (RP) is the predominant form of inherited retinal degenerations (IRDs) caused by abnormalities and loss of photoreceptor cells ensuing diminishment of vision. RP is a heterogenous genetic disorder associated with mutations in over 80 genes, showing various inheritance patterns. Laboratory mouse models are important for our understanding of disease mechanisms, modifier effects, and development of therapeutic modalities. In this review, we have summarized a comprehensive comparison of our previously reported Fam161a knockout (KO) mouse model with other well-studied RP mouse models, Fam161aGT/GT, Pde6brd1, Nr2e3rd7, Rpgrrd9, and Pde6brd10 using structural and functional analysis of the retina. Fam161atm1b/tm1b mouse models are important for developing novel therapies and mainly AAV-based gene therapy and translational read-through-inducing drugs." @default.
- W4384120112 created "2023-07-14" @default.
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- W4384120112 date "2023-01-01" @default.
- W4384120112 modified "2023-10-11" @default.
- W4384120112 title "Morphological and Functional Comparison of Mice Models for Retinitis Pigmentosa" @default.
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- W4384120112 doi "https://doi.org/10.1007/978-3-031-27681-1_53" @default.
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