Matches in SemOpenAlex for { <https://semopenalex.org/work/W4384120131> ?p ?o ?g. }
- W4384120131 abstract "The ATN's different modalities (fluids and neuroimaging) for each of the Aβ (A), tau (T), and neurodegeneration (N) elements are used for the biological diagnosis of Alzheimer's disease (AD). We aim to identify which ATN category achieves the highest potential for diagnosis and predictive accuracy of longitudinal cognitive decline.Based on the availability of plasma ATN biomarkers (plasma-derived Aβ42/40 , p-tau181, NFL, respectively), CSF ATN biomarkers (CSF-derived Aβ42 /Aβ40 , p-tau181, NFL), and neuroimaging ATN biomarkers (18F-florbetapir (FBP) amyloid-PET, 18F-flortaucipir (FTP) tau-PET, and fluorodeoxyglucose (FDG)-PET), a total of 2340 participants were selected from ADNI.Our data analysis indicates that the area under curves (AUCs) of CSF-A, neuroimaging-T, and neuroimaging-N were ranked the top three ATN candidates for accurate diagnosis of AD. Moreover, neuroimaging ATN biomarkers display the best predictive ability for longitudinal cognitive decline among the three categories. To note, neuroimaging-T correlates well with cognitive performances in a negative correlation manner. Meanwhile, participants in the N element positive group, especially the CSF-N positive group, experience the fastest cognitive decline compared with other groups defined by ATN biomarkers. In addition, the voxel-wise analysis showed that CSF-A related to tau accumulation and FDG-PET indexes more strongly in subjects with MCI stage. According to our analysis of the data, the best three ATN candidates for a precise diagnosis of AD are CSF-A, neuroimaging-T, and neuroimaging-N.Collectively, our findings suggest that plasma, CSF, and neuroimaging biomarkers differ considerably within the ATN framework; the most accurate target biomarkers for diagnosing AD were the CSF-A, neuroimaging-T, and neuroimaging-N within each ATN modality. Moreover, neuroimaging-T and CSF-N both show excellent ability in the prediction of cognitive decline in two different dimensions." @default.
- W4384120131 created "2023-07-14" @default.
- W4384120131 creator A5008599644 @default.
- W4384120131 creator A5016860101 @default.
- W4384120131 creator A5041466850 @default.
- W4384120131 creator A5041753664 @default.
- W4384120131 creator A5043058286 @default.
- W4384120131 creator A5048788845 @default.
- W4384120131 creator A5085295021 @default.
- W4384120131 creator A5090857932 @default.
- W4384120131 date "2023-07-12" @default.
- W4384120131 modified "2023-10-17" @default.
- W4384120131 title "Alzheimer's disease diagnostic accuracy by fluid and neuroimaging <scp>ATN</scp> framework" @default.
- W4384120131 cites W1847168837 @default.
- W4384120131 cites W1887821162 @default.
- W4384120131 cites W1934117767 @default.
- W4384120131 cites W1968811469 @default.
- W4384120131 cites W1974897313 @default.
- W4384120131 cites W2004691878 @default.
- W4384120131 cites W2024719735 @default.
- W4384120131 cites W2044614452 @default.
- W4384120131 cites W2069743064 @default.
- W4384120131 cites W2097903748 @default.
- W4384120131 cites W2151384687 @default.
- W4384120131 cites W2196038229 @default.
- W4384120131 cites W2327547544 @default.
- W4384120131 cites W2346847240 @default.
- W4384120131 cites W2498795028 @default.
- W4384120131 cites W2529649944 @default.
- W4384120131 cites W2556389549 @default.
- W4384120131 cites W2582524520 @default.
- W4384120131 cites W2763470121 @default.
- W4384120131 cites W2772836221 @default.
- W4384120131 cites W2789976306 @default.
- W4384120131 cites W2791135917 @default.
- W4384120131 cites W2798054687 @default.
- W4384120131 cites W2809499549 @default.
- W4384120131 cites W2895381107 @default.
- W4384120131 cites W2899635607 @default.
- W4384120131 cites W2909883195 @default.
- W4384120131 cites W2911248861 @default.
- W4384120131 cites W2942151633 @default.
- W4384120131 cites W2945980668 @default.
- W4384120131 cites W2966191040 @default.
- W4384120131 cites W2979624665 @default.
- W4384120131 cites W2984229501 @default.
- W4384120131 cites W2998707549 @default.
- W4384120131 cites W3004903726 @default.
- W4384120131 cites W3018431352 @default.
- W4384120131 cites W3020992444 @default.
- W4384120131 cites W3038433131 @default.
- W4384120131 cites W3045997188 @default.
- W4384120131 cites W3092829183 @default.
- W4384120131 cites W3093546635 @default.
- W4384120131 cites W3093654837 @default.
- W4384120131 cites W3105808417 @default.
- W4384120131 cites W3107511586 @default.
- W4384120131 cites W3114927390 @default.
- W4384120131 cites W3119309452 @default.
- W4384120131 cites W3182597378 @default.
- W4384120131 cites W3191270694 @default.
- W4384120131 cites W3195656026 @default.
- W4384120131 cites W3198052269 @default.
- W4384120131 cites W4206529560 @default.
- W4384120131 cites W4206774749 @default.
- W4384120131 doi "https://doi.org/10.1111/cns.14357" @default.
- W4384120131 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37438991" @default.
- W4384120131 hasPublicationYear "2023" @default.
- W4384120131 type Work @default.
- W4384120131 citedByCount "0" @default.
- W4384120131 crossrefType "journal-article" @default.
- W4384120131 hasAuthorship W4384120131A5008599644 @default.
- W4384120131 hasAuthorship W4384120131A5016860101 @default.
- W4384120131 hasAuthorship W4384120131A5041466850 @default.
- W4384120131 hasAuthorship W4384120131A5041753664 @default.
- W4384120131 hasAuthorship W4384120131A5043058286 @default.
- W4384120131 hasAuthorship W4384120131A5048788845 @default.
- W4384120131 hasAuthorship W4384120131A5085295021 @default.
- W4384120131 hasAuthorship W4384120131A5090857932 @default.
- W4384120131 hasBestOaLocation W43841201311 @default.
- W4384120131 hasConcept C142724271 @default.
- W4384120131 hasConcept C15744967 @default.
- W4384120131 hasConcept C169760540 @default.
- W4384120131 hasConcept C169900460 @default.
- W4384120131 hasConcept C2775842073 @default.
- W4384120131 hasConcept C2778373026 @default.
- W4384120131 hasConcept C2779134260 @default.
- W4384120131 hasConcept C2779483572 @default.
- W4384120131 hasConcept C2984863031 @default.
- W4384120131 hasConcept C502032728 @default.
- W4384120131 hasConcept C58693492 @default.
- W4384120131 hasConcept C71924100 @default.
- W4384120131 hasConceptScore W4384120131C142724271 @default.
- W4384120131 hasConceptScore W4384120131C15744967 @default.
- W4384120131 hasConceptScore W4384120131C169760540 @default.
- W4384120131 hasConceptScore W4384120131C169900460 @default.
- W4384120131 hasConceptScore W4384120131C2775842073 @default.
- W4384120131 hasConceptScore W4384120131C2778373026 @default.
- W4384120131 hasConceptScore W4384120131C2779134260 @default.
- W4384120131 hasConceptScore W4384120131C2779483572 @default.