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- W4384120190 abstract "The retinal pigment epithelium (RPE) ensures different functions crucial for photoreceptor survival, and thus for vision, such as photoreceptor outer segments (POS) phagocytosis and retinal adhesion. Both follow a circadian rhythm with an activity peak occurring respectively 1.5–2 and 3.5 h after light onset. Interestingly, we showed that two rodent models, β5−/− and Prpf31+/− mice, display distinct alterations in both functions leading to different phenotypes. Indeed, the phagocytic peak totally disappears in β5 knockout mice but is attenuated and shifted in Prpf31+/− mice. Conversely, the retinal adhesion peak only attenuated in β5−/− mice is lost in Prpf31+/− mice. These distinct alterations have different consequences on retinal homeostasis proportional to the observed defects: β5−/− mice progressively lose vision and accumulate RPE lipofuscin deposits, while Prpf31+/− mice develop RPE metabolic dysfunctions and gradual structural modifications indicative of cellular stress. Hence, animal models are useful to understand the importance of the proper regulation of these functions." @default.
- W4384120190 created "2023-07-14" @default.
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- W4384120190 date "2023-01-01" @default.
- W4384120190 modified "2023-09-25" @default.
- W4384120190 title "The Retinal Pigment Epithelium: Cells That Know the Beat!" @default.
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- W4384120190 doi "https://doi.org/10.1007/978-3-031-27681-1_79" @default.
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