Matches in SemOpenAlex for { <https://semopenalex.org/work/W4384120622> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W4384120622 endingPage "554" @default.
- W4384120622 startingPage "549" @default.
- W4384120622 abstract "Inherited retinal degenerations (IRD) encompasses a group of heterogeneous disorders causing debilitating visual diseases and blindness, affecting more than two million people worldwide, in all age groups. The inheritance patterns vary from autosomal dominant, autosomal recessive, X-linked, and sporadic with mutations in over 260 genes identified to date. Despite the significant advances in clinical diagnosis, there is no effective treatment available. Human-induced pluripotent stem cells (hiPSC) derived in vitro 3D retinal organoids offer a powerful preclinical tool to investigate the molecular mechanism(s) of inherited diseases. Organoids have the potential for the development of personalized therapies by modeling the disease-specific and patient-specific IRD. This mini-review will elaborate on the utility of the advanced culture model system by focusing on staging the in vitro human retinogenesis, modeling retinal diseases, and as a tool for testing potential therapeutic approaches to restore or prevent vision loss in affected individuals." @default.
- W4384120622 created "2023-07-14" @default.
- W4384120622 creator A5047248049 @default.
- W4384120622 creator A5070151799 @default.
- W4384120622 date "2023-01-01" @default.
- W4384120622 modified "2023-09-23" @default.
- W4384120622 title "Retinal Organoids: A Human Model System for Development, Diseases, and Therapies" @default.
- W4384120622 cites W139824189 @default.
- W4384120622 cites W1518338854 @default.
- W4384120622 cites W2059743094 @default.
- W4384120622 cites W2072127633 @default.
- W4384120622 cites W2547540394 @default.
- W4384120622 cites W2604275021 @default.
- W4384120622 cites W2770041529 @default.
- W4384120622 cites W2791277809 @default.
- W4384120622 cites W2804664596 @default.
- W4384120622 cites W2883753288 @default.
- W4384120622 cites W2883897094 @default.
- W4384120622 cites W2904334833 @default.
- W4384120622 cites W2947648070 @default.
- W4384120622 cites W3005472012 @default.
- W4384120622 cites W3006890237 @default.
- W4384120622 cites W3010309414 @default.
- W4384120622 cites W3013848031 @default.
- W4384120622 cites W3028914388 @default.
- W4384120622 cites W3035100062 @default.
- W4384120622 cites W3118034245 @default.
- W4384120622 cites W3124056521 @default.
- W4384120622 cites W3171218066 @default.
- W4384120622 cites W3201225423 @default.
- W4384120622 doi "https://doi.org/10.1007/978-3-031-27681-1_80" @default.
- W4384120622 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37440085" @default.
- W4384120622 hasPublicationYear "2023" @default.
- W4384120622 type Work @default.
- W4384120622 citedByCount "0" @default.
- W4384120622 crossrefType "book-chapter" @default.
- W4384120622 hasAuthorship W4384120622A5047248049 @default.
- W4384120622 hasAuthorship W4384120622A5070151799 @default.
- W4384120622 hasConcept C104317684 @default.
- W4384120622 hasConcept C107459253 @default.
- W4384120622 hasConcept C118487528 @default.
- W4384120622 hasConcept C119767625 @default.
- W4384120622 hasConcept C142724271 @default.
- W4384120622 hasConcept C145103041 @default.
- W4384120622 hasConcept C169760540 @default.
- W4384120622 hasConcept C2779134260 @default.
- W4384120622 hasConcept C2780827179 @default.
- W4384120622 hasConcept C2780929884 @default.
- W4384120622 hasConcept C2910924664 @default.
- W4384120622 hasConcept C2988867146 @default.
- W4384120622 hasConcept C31695470 @default.
- W4384120622 hasConcept C54355233 @default.
- W4384120622 hasConcept C60644358 @default.
- W4384120622 hasConcept C70721500 @default.
- W4384120622 hasConcept C71924100 @default.
- W4384120622 hasConcept C86803240 @default.
- W4384120622 hasConcept C98108389 @default.
- W4384120622 hasConceptScore W4384120622C104317684 @default.
- W4384120622 hasConceptScore W4384120622C107459253 @default.
- W4384120622 hasConceptScore W4384120622C118487528 @default.
- W4384120622 hasConceptScore W4384120622C119767625 @default.
- W4384120622 hasConceptScore W4384120622C142724271 @default.
- W4384120622 hasConceptScore W4384120622C145103041 @default.
- W4384120622 hasConceptScore W4384120622C169760540 @default.
- W4384120622 hasConceptScore W4384120622C2779134260 @default.
- W4384120622 hasConceptScore W4384120622C2780827179 @default.
- W4384120622 hasConceptScore W4384120622C2780929884 @default.
- W4384120622 hasConceptScore W4384120622C2910924664 @default.
- W4384120622 hasConceptScore W4384120622C2988867146 @default.
- W4384120622 hasConceptScore W4384120622C31695470 @default.
- W4384120622 hasConceptScore W4384120622C54355233 @default.
- W4384120622 hasConceptScore W4384120622C60644358 @default.
- W4384120622 hasConceptScore W4384120622C70721500 @default.
- W4384120622 hasConceptScore W4384120622C71924100 @default.
- W4384120622 hasConceptScore W4384120622C86803240 @default.
- W4384120622 hasConceptScore W4384120622C98108389 @default.
- W4384120622 hasLocation W43841206221 @default.
- W4384120622 hasLocation W43841206222 @default.
- W4384120622 hasOpenAccess W4384120622 @default.
- W4384120622 hasPrimaryLocation W43841206221 @default.
- W4384120622 hasRelatedWork W2014372623 @default.
- W4384120622 hasRelatedWork W2025187846 @default.
- W4384120622 hasRelatedWork W2075483847 @default.
- W4384120622 hasRelatedWork W2330436460 @default.
- W4384120622 hasRelatedWork W2530681873 @default.
- W4384120622 hasRelatedWork W2912811132 @default.
- W4384120622 hasRelatedWork W3032525775 @default.
- W4384120622 hasRelatedWork W3033076918 @default.
- W4384120622 hasRelatedWork W3044088143 @default.
- W4384120622 hasRelatedWork W4210402978 @default.
- W4384120622 isParatext "false" @default.
- W4384120622 isRetracted "false" @default.
- W4384120622 workType "book-chapter" @default.