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• W4384120819 abstract "Survivin is highly expressed in various malignant tumor cells and positively related to poor prognosis and drug resistance. This study aimed to explore the role of non-coding splice variant of Survivin, BIRC5-206 (ENST00000589892.1) in the progression of nasopharyngeal carcinoma (NPC), a malignant tumor that highly occurs in the southern region of China.shRNA was used to knockdown BIRC5-206 mRNA level in CNE-2 and HOPNE-1 cells. Then, cell death, migration, invasion and clone formation ability of CNE-2 and HOPNE-1 cells were detected by flow cytometry, scratch-healing experiments, transwell invasion assay and clone formation assay, respectively. CD44+ and CD133+ positive cells were determined via Flow cytometry. Oct4, Nanog and SOX2 protein levels in CNE-2 and HOPNE-1 cells were measured by Western blot.BIRC5-206 decreased significantly in NPC cell lines. Silencing of BIRC5-206 suppressed the apoptosis, facilitated the migration, invasion and proliferation of both HONE1 and CNE-2 cells. In addition, knockdown of BIRC5-206 significantly promoted the expression cancer stem cell marker (CD44 and CD133) and pluripotency markers (Oct4, Sox2 and Nanog).BIRC5-206 might facilitate NPC tumor progression by inducing the transformation of NPC cells to cancer stem cells." @default.
• W4384120819 created "2023-07-14" @default.
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• W4384120819 date "2023-05-01" @default.
• W4384120819 modified "2023-10-18" @default.
• W4384120819 title "Low Expression of BIRC5-206 Promotes Cancer Progression in Nasopharyngeal Carcinoma via Enhancing Expression of Stem Cell Markers." @default.
• W4384120819 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37437934" @default.
• W4384120819 hasPublicationYear "2023" @default.
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