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- W4384126605 abstract "Abstract ADAPTOR-ASSOCIATED PROTEIN KINASE1 (AAK1) is a known regulator of clathrin-mediated endocytosis in mammals. Human AAK1 phosphorylates the μ2 subunit of the ADAPTOR PROTEIN-2 (AP-2) complex (AP2M) and plays important roles in cell differentiation and development. Previous interactome studies discovered the association of AAK1 with AP-2 in Arabidopsis (Arabidopsis thaliana), but its function was unclear. Here, genetic analysis revealed that the Arabidopsis aak1 and ap2m mutants both displayed altered root tropic growth, including impaired touch- and gravity-sensing responses. In Arabidopsis, AAK1-phosphorylated AP2M on Thr-163, and expression of the phospho-null version of AP2M in the ap2m mutant led to an aak1-like phenotype, whereas the phospho-mimic forms of AP2M rescued the aak1 mutant. In addition, we found that the AAK1-dependent phosphorylation state of AP2M modulates the frequency distribution of endocytosis. Our data indicate that the phosphorylation of AP2M on Thr-163 by AAK1 fine-tunes endocytosis in the Arabidopsis root to control its tropic growth." @default.
- W4384126605 created "2023-07-14" @default.
- W4384126605 creator A5001748676 @default.
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- W4384126605 creator A5064872690 @default.
- W4384126605 creator A5089574246 @default.
- W4384126605 date "2023-07-13" @default.
- W4384126605 modified "2023-09-24" @default.
- W4384126605 title "Phosphorylation of ADAPTOR PROTEIN-2 μ-adaptin by ADAPTOR-ASSOCIATED KINASE1 regulates the tropic growth of Arabidopsis roots" @default.
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- W4384126605 doi "https://doi.org/10.1093/plcell/koad141" @default.
- W4384126605 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37440281" @default.
- W4384126605 hasPublicationYear "2023" @default.
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