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- W4384126720 abstract "Replication of the mitochondrial genome and expression of the genes it encodes both depend on a sufficient supply of nucleotides to mitochondria. Accordingly, dysregulated nucleotide metabolism not only destabilises the mitochondrial genome, but also affects its transcription. Here, we report that a mitochondrial nucleoside diphosphate kinase, NME6, supplies mitochondria with pyrimidine ribonucleotides that are necessary for the transcription of mitochondrial genes. Loss of NME6 function leads to the depletion of mitochondrial transcripts, as well as destabilisation of the electron transport chain and impaired oxidative phosphorylation. These deficiencies are rescued by an exogenous supply of pyrimidine ribonucleosides. Moreover, NME6 is required for the maintenance of mitochondrial DNA when the access to cytosolic pyrimidine deoxyribonucleotides is limited. Our results therefore reveal an important role for ribonucleotide salvage in mitochondrial gene expression." @default.
- W4384126720 created "2023-07-14" @default.
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- W4384126720 date "2023-07-13" @default.
- W4384126720 modified "2023-10-06" @default.
- W4384126720 title "Ribonucleotide synthesis by <scp>NME6</scp> fuels mitochondrial gene expression" @default.
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- W4384126720 doi "https://doi.org/10.15252/embj.2022113256" @default.
- W4384126720 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37439264" @default.
- W4384126720 hasPublicationYear "2023" @default.
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