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- W4384126827 abstract "Formation of intraretinal capillaries and inner blood-retinal barrierBlood retinal barrier during development requires norrinNorrin, a ligand of the canonical wingless/integrated (Wnt)/β-cateninβ-catenin signaling pathway. Here we addressed the question whether retinal pigmented epitheliumRetinal pigmented epithelium (RPERetinal pigment epithelium (RPE))-derived overexpression of norrinNorrin in transgenic miceMice rescues the vascular phenotype caused by norrin deficiency. To this end, we generated NdpKO/Rpe65-Norrin miceMice and analyzed the activation of β-cateninβ-catenin signaling, the development of intraretinal capillaries, and the expression of blood-retinal barrierBlood retinal barrier marker molecules. RPE-derived norrinNorrin induced retinal β-cateninβ-catenin signaling but failed to rescue the vascular developmental defects and the breakdown of the blood-retinal barrierBlood retinal barrier in norrin-deficient miceMice. Sites of ectopic norrinNorrin expression and the amounts of secreted transgenic proteinProteins are critical factors to enable the angiogenic properties of norrinNorrin." @default.
- W4384126827 created "2023-07-14" @default.
- W4384126827 creator A5022032393 @default.
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- W4384126827 date "2023-01-01" @default.
- W4384126827 modified "2023-09-23" @default.
- W4384126827 title "Retinal Pigmented Epithelium-Derived Ectopic Norrin Does Not Promote Intraretinal Angiogenesis in Transgenic Mice" @default.
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- W4384126827 doi "https://doi.org/10.1007/978-3-031-27681-1_35" @default.
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- W4384126827 hasPublicationYear "2023" @default.
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