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- W4384126869 abstract "Abstract Tumor stemness is associated with the recurrence and incurability of colorectal cancer (CRC), which lacks effective therapeutic targets and drugs. Glycinamide ribonucleotide transformylase (GART) fulfills an important role in numerous types of malignancies. The present study aims to identify the underlying mechanism through which GART may promote CRC stemness, as to developing novel therapeutic methods. An elevated level of GART is associated with poor outcomes in CRC patients and promotes the proliferation and migration of CRC cells. CD133 + cells with increased GART expression possess higher tumorigenic and proliferative capabilities both in vitro and in vivo. GART is identified to have a novel methyltransferase function, whose enzymatic activity center is located at the E948 site. GART also enhances the stability of RuvB‐like AAA ATPase 1 (RUVBL1) through methylating its K7 site, which consequently aberrantly activates the Wnt/β‐catenin signaling pathway to induce tumor stemness. Pemetrexed (PEM), a compound targeting GART, combined with other chemotherapy drugs greatly suppresses tumor growth both in a PDX model and in CRC patients. The present study demonstrates a novel methyltransferase function of GART and the role of the GART/RUVBL1/β‐catenin signaling axis in promoting CRC stemness. PEM may be a promising therapeutic agent for the treatment of CRC." @default.
- W4384126869 created "2023-07-14" @default.
- W4384126869 creator A5021687717 @default.
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- W4384126869 creator A5078046664 @default.
- W4384126869 date "2023-07-13" @default.
- W4384126869 modified "2023-10-16" @default.
- W4384126869 title "GART Functions as a Novel Methyltransferase in the RUVBL1/β‐Catenin Signaling Pathway to Promote Tumor Stemness in Colorectal Cancer" @default.
- W4384126869 cites W1007961504 @default.
- W4384126869 cites W116758555 @default.
- W4384126869 cites W133253872 @default.
- W4384126869 cites W1492849291 @default.
- W4384126869 cites W1566165116 @default.
- W4384126869 cites W1967794100 @default.
- W4384126869 cites W1967882987 @default.
- W4384126869 cites W1969430061 @default.
- W4384126869 cites W1972932862 @default.
- W4384126869 cites W1974322725 @default.
- W4384126869 cites W1978514668 @default.
- W4384126869 cites W1982714628 @default.
- W4384126869 cites W1987012261 @default.
- W4384126869 cites W1993329761 @default.
- W4384126869 cites W1993816996 @default.
- W4384126869 cites W2001544973 @default.
- W4384126869 cites W2005600213 @default.
- W4384126869 cites W2006769107 @default.
- W4384126869 cites W2023351030 @default.
- W4384126869 cites W2031945343 @default.
- W4384126869 cites W2033715459 @default.
- W4384126869 cites W2036796490 @default.
- W4384126869 cites W2046705094 @default.
- W4384126869 cites W2056868516 @default.
- W4384126869 cites W2082041065 @default.
- W4384126869 cites W2087485016 @default.
- W4384126869 cites W2093405022 @default.
- W4384126869 cites W2093531978 @default.
- W4384126869 cites W2096844968 @default.
- W4384126869 cites W2103244742 @default.
- W4384126869 cites W2104227921 @default.
- W4384126869 cites W2108353340 @default.
- W4384126869 cites W2122465033 @default.
- W4384126869 cites W2124715710 @default.
- W4384126869 cites W2126932298 @default.
- W4384126869 cites W2131729719 @default.
- W4384126869 cites W2140381750 @default.
- W4384126869 cites W2141405250 @default.
- W4384126869 cites W2142423276 @default.
- W4384126869 cites W2143984312 @default.
- W4384126869 cites W2149433168 @default.
- W4384126869 cites W2150764066 @default.
- W4384126869 cites W2156983594 @default.
- W4384126869 cites W2157910818 @default.
- W4384126869 cites W2164679066 @default.
- W4384126869 cites W2165087323 @default.
- W4384126869 cites W2177163333 @default.
- W4384126869 cites W2287568757 @default.
- W4384126869 cites W2302003756 @default.
- W4384126869 cites W2462704189 @default.
- W4384126869 cites W2474112260 @default.
- W4384126869 cites W2504169559 @default.
- W4384126869 cites W2529453809 @default.
- W4384126869 cites W2535734390 @default.
- W4384126869 cites W2549615193 @default.
- W4384126869 cites W2771001400 @default.
- W4384126869 cites W2789844784 @default.
- W4384126869 cites W2809263305 @default.
- W4384126869 cites W2871099016 @default.
- W4384126869 cites W2889646458 @default.
- W4384126869 cites W2891589486 @default.
- W4384126869 cites W2893961844 @default.
- W4384126869 cites W2915675655 @default.
- W4384126869 cites W2933162187 @default.
- W4384126869 cites W2937343665 @default.
- W4384126869 cites W2950359183 @default.
- W4384126869 cites W2951411205 @default.
- W4384126869 cites W2954194261 @default.
- W4384126869 cites W2965511892 @default.
- W4384126869 cites W2974584278 @default.
- W4384126869 cites W2981002467 @default.
- W4384126869 cites W2982326681 @default.
- W4384126869 cites W2986542121 @default.
- W4384126869 cites W2995035247 @default.
- W4384126869 cites W2997958662 @default.
- W4384126869 cites W3005733169 @default.
- W4384126869 cites W3006030203 @default.
- W4384126869 cites W3029252496 @default.
- W4384126869 cites W3046940301 @default.
- W4384126869 cites W3049643238 @default.
- W4384126869 cites W3086889801 @default.
- W4384126869 cites W3094834180 @default.
- W4384126869 cites W3096187061 @default.
- W4384126869 cites W3096921681 @default.