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• W4384126877 abstract "ABSTRACT For a long time, self-renewing and multipotent hematopoietic stem cells (HSCs) have been thought to make a major contribution to both embryonic and adult hematopoiesis. The canonical hematopoietic hierarchy illustrating HSC self-renewal and multipotency has been established mainly based on invasive functional assays (e.g. transplantation or colony-forming units in the spleen and in culture), which evaluate the cellular potentials of HSCs. With the extensive applications of non-invasive cell fate-mapping strategies, recent lineage tracing-based studies have suggested that not all native hematopoiesis is established via the hierarchical differentiation of HSCs. By contrast, hematopoietic progenitor cells (HPCs) are a dominant contributor to both embryonic and young adult hematopoiesis. These new findings help redefine the cellular origins of embryonic and adult hematopoiesis under native conditions, and emphasize the differences in revealing HSC potential versus HSC fate using distinct approaches during stress and native hematopoiesis. Here, we review recent advances in HPC and HSC development, and provide an updated perspective to incorporate these new findings with our traditional understanding of developmental and adult hematopoiesis." @default.
• W4384126877 created "2023-07-14" @default.
• W4384126877 creator A5022118565 @default.
• W4384126877 creator A5036658104 @default.
• W4384126877 creator A5078406449 @default.
• W4384126877 date "2023-07-13" @default.
• W4384126877 modified "2023-10-14" @default.
• W4384126877 title "Revisiting the lineage contribution of hematopoietic stem and progenitor cells" @default.
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