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- W4384126883 abstract "Matrix metalloproteinases (MMPs) are a tightly regulated family of proteolytic enzymes that break down extracellular matrix (ECM) and basement membrane components. Because it is associated with development, morphogenesis, tissue remodeling, and repair, ECM remodeling is an important mechanism. MMPs are thought to act as a double-edged sword, as they contribute to maintaining photoreceptors/retinal pigment epithelium (RPE)/Bruch’s membrane (BM)/choroid complex homeostasis and also contribute to the onset and progression of age-related macular degeneration (AMD). Polymorphisms and/or altered expression in MMPs and their tissue inhibitors (TIMPs) are associated with age-related macular degeneration (AMD). Here, we review the evidence for MMPs’ role in the onset and progression of AMD via addressing their regulation and TIMPs’ significant regulatory functions." @default.
- W4384126883 created "2023-07-14" @default.
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- W4384126883 date "2023-01-01" @default.
- W4384126883 modified "2023-09-23" @default.
- W4384126883 title "Disturbed Matrix Metalloproteinases Activity in Age-Related Macular Degeneration" @default.
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- W4384126883 doi "https://doi.org/10.1007/978-3-031-27681-1_4" @default.
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