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• W4384126954 endingPage "156293" @default.
• W4384126954 startingPage "156293" @default.
• W4384126954 abstract "IL-22 has emerged as a crucial cytokine mediating protective response against pathogens and tissue regeneration. Dysregulated production of IL-22 has been shown to play a pivotal role in the pathogenesis of various diseases like malignant tumours, viral, cardiovascular, allergic and autoimmune disorders. Interleukin 22 belongs to IFN–IL-10 cytokine family. It is a major proinflammatory cytokine secreted by activated Th1 cells (Th22), though can also be secreted by many other immune cells like group 3 innate lymphocytes, γδ T cells, NK cells, NK T cells, and mucosal associated invariant T cells. Th22 cells exclusively release IL-22 but not IL-17 or IFN-γ (as Th1 cells releases IFN-γ along with IL-22 and Th17 cells releases IL-17 along with IL-22) and also express aryl hydrocarbon receptor as the key transcription factor. Th22 cells also exhibit expression of chemokine receptor CCR6 and skin-homing receptors CCR4 and CCR10 indicating the involvement of this subset in bolstering epithelial barrier immunity and promoting secretion of antimicrobial peptides (AMPs) from intestinal epithelial cells. The function of IL-22 is modulated by IL-22 binding protein (binds to IL-22 and inhibits it binding to its cell surface receptor); which serves as a competitor for IL-22R1 chain of IL-22 receptor. The pathogenic and protective nature of the Th22 cells is modulated both by the site of infected tissue and the type of disease pathology. This review aims to discuss key features of IL-22 biology, comparisons between IL and 22 and IFN-γ and its role as a potential immune therapy target in different maladies." @default.
• W4384126954 created "2023-07-14" @default.
• W4384126954 creator A5064834072 @default.
• W4384126954 creator A5073728973 @default.
• W4384126954 date "2023-09-01" @default.
• W4384126954 modified "2023-09-27" @default.
• W4384126954 title "IL-22 as a target for therapeutic intervention: Current knowledge on its role in various diseases" @default.
• W4384126954 cites W1228965893 @default.
• W4384126954 cites W1507781793 @default.
• W4384126954 cites W1523268063 @default.
• W4384126954 cites W1532206496 @default.
• W4384126954 cites W1535831265 @default.
• W4384126954 cites W1559033008 @default.
• W4384126954 cites W1560379370 @default.
• W4384126954 cites W1569250960 @default.
• W4384126954 cites W1576903429 @default.
• W4384126954 cites W1579108180 @default.
• W4384126954 cites W1587070562 @default.
• W4384126954 cites W1601024866 @default.
• W4384126954 cites W1646851899 @default.
• W4384126954 cites W1665307666 @default.
• W4384126954 cites W168918095 @default.
• W4384126954 cites W1771055786 @default.
• W4384126954 cites W1793351365 @default.
• W4384126954 cites W1821979477 @default.
• W4384126954 cites W1833097568 @default.
• W4384126954 cites W1915760257 @default.
• W4384126954 cites W1964704428 @default.
• W4384126954 cites W1966886092 @default.
• W4384126954 cites W1972140301 @default.
• W4384126954 cites W1978283420 @default.
• W4384126954 cites W1979058179 @default.
• W4384126954 cites W1979364731 @default.
• W4384126954 cites W1979408872 @default.
• W4384126954 cites W1980444116 @default.
• W4384126954 cites W1980542836 @default.
• W4384126954 cites W1983563263 @default.
• W4384126954 cites W1987784314 @default.
• W4384126954 cites W1988980084 @default.
• W4384126954 cites W1991233072 @default.
• W4384126954 cites W1993003564 @default.
• W4384126954 cites W1994343545 @default.
• W4384126954 cites W1995961172 @default.
• W4384126954 cites W2000851235 @default.
• W4384126954 cites W2005359518 @default.
• W4384126954 cites W2006530491 @default.
• W4384126954 cites W2006711580 @default.
• W4384126954 cites W2007121925 @default.
• W4384126954 cites W2008751364 @default.
• W4384126954 cites W2009066619 @default.
• W4384126954 cites W2011391670 @default.
• W4384126954 cites W2011825302 @default.
• W4384126954 cites W2012077729 @default.
• W4384126954 cites W2012555541 @default.
• W4384126954 cites W2013174190 @default.
• W4384126954 cites W2014729966 @default.
• W4384126954 cites W2026791577 @default.
• W4384126954 cites W2027756860 @default.
• W4384126954 cites W2028173353 @default.
• W4384126954 cites W2033292760 @default.
• W4384126954 cites W2034965950 @default.
• W4384126954 cites W2038131331 @default.
• W4384126954 cites W2040015333 @default.
• W4384126954 cites W2040297369 @default.
• W4384126954 cites W2040520058 @default.
• W4384126954 cites W2045854538 @default.
• W4384126954 cites W2047089179 @default.
• W4384126954 cites W2047154603 @default.
• W4384126954 cites W2055039856 @default.
• W4384126954 cites W2055912677 @default.
• W4384126954 cites W2056585878 @default.
• W4384126954 cites W2058520337 @default.
• W4384126954 cites W2059807214 @default.
• W4384126954 cites W2060458742 @default.
• W4384126954 cites W2067353642 @default.
• W4384126954 cites W2072937250 @default.
• W4384126954 cites W2074205207 @default.
• W4384126954 cites W2074558714 @default.
• W4384126954 cites W2078482635 @default.
• W4384126954 cites W2079557777 @default.
• W4384126954 cites W2080994828 @default.
• W4384126954 cites W2082159115 @default.
• W4384126954 cites W2082450021 @default.
• W4384126954 cites W2082525626 @default.
• W4384126954 cites W2082639172 @default.
• W4384126954 cites W2083576842 @default.
• W4384126954 cites W2083764107 @default.
• W4384126954 cites W2086757562 @default.
• W4384126954 cites W2091674262 @default.
• W4384126954 cites W2091845172 @default.
• W4384126954 cites W2093543014 @default.
• W4384126954 cites W2094438002 @default.
• W4384126954 cites W2095194898 @default.
• W4384126954 cites W2101068992 @default.
• W4384126954 cites W2106464597 @default.
• W4384126954 cites W2107066107 @default.
• W4384126954 cites W2111494418 @default.
• W4384126954 cites W2111503059 @default.

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