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• W4384129440 abstract "Abstract Aims Esophageal cancer (EC) and gut microbiota are reported to be clinically relevant but their genetic association is unclear. We carried out a bidirectional MR analyses to assess the casual relationship between EC and gut microbiota from fecal samples. Methods The microbiome genome-wide association studies (GWAS) data of 18,340 individuals provided by MiBioGen consortium and the EC GWAS data (740 esophageal cancers cases and 372,016 controls) provided by UK Biobank were respectively utilized as exposure and/or outcome data. Reliable single nucleotide polymorphisms (SNPs) were obtained after rigorous screening. A bidirectional Mendelian randomization (MR) analysis was conducted using the inverse-variance weighted (IVW) method. The sensitivity analyses including the MR-Egger method, weighted median, MR-PRESSO and mode methods were performed to examine the stability, heterogeneity and pleiotropy of the results. Results Forward MR analysis revealed genetic liability to gut microbiota was associated with a higher risk of EC ( Coprobacter (OR 1.001, 95%CI 1.000-1.002); Ruminococcus1 (OR 1.001, 95%CI 1.000-1.002); Turicibacter (OR 0.999, 95%CI 0.998-1.000); Senegalimassilia (OR 1.002, 95%CI 1.000-1.003); Veillonella (OR 1.001, 95%CI 1.000-1.002)) or a significantly lower risk of EC ( Eubacterium oxidoreducens (OR 0.999, 95%CI 0.998-1.000); Lachnospira (OR 0.998, 95%CI 0.996-1.000); Romboutsia (OR 0.999, 95%CI 0.998-1.000)). Reverse MR analysis showed that genetic liability to EC was also causally linked to increased susceptibility of gut microbiota dysbiosis (genera Eggerthella (Beta 37.63, 95%CI 4.76–70.50); Coprococcus2 (Beta 23.90, 95%CI 1.65–46.15); ChristensenellaceaeR.7 (Beta 22.75, 95%CI 4.22–41.28); genera Intestinimonas (OR -33.24, 95%CI-54.90–11.58)). Conclusions Our findings supported a bidirectionally causal relationship between gut microbiota and EC, implying the potential of gut microbiota as novel biomarkers and therapeutic drugs for EC." @default.
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• W4384129440 date "2023-07-13" @default.
• W4384129440 modified "2023-10-16" @default.
• W4384129440 title "The Causal Role of Esophageal Cancer and Gut Microbiota: A Bidirectional Mendelian Randomization Study" @default.
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• W4384129440 doi "https://doi.org/10.21203/rs.3.rs-3149703/v1" @default.
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