Matches in SemOpenAlex for { <https://semopenalex.org/work/W4384130147> ?p ?o ?g. }
Showing items 1 to 66 of
66
with 100 items per page.
- W4384130147 abstract "Cannabis, the most consumed psychoactive drug in the world, is increasingly used by pregnant women. However, while cannabinoid receptors are expressed in the early embryo, the impact of phytocannabinoids exposure on early embryonic processes is lacking. Here, we leverage a stepwise in vitro differentiation system that captures early embryonic developmental cascade to investigate the impact of exposure to the most abundant phytocannabinoid, Δ9-tetrahydrocannabinol (Δ9-THC). We demonstrate that Δ9-THC increases the proliferation of naïve mouse embryonic stem cells (ESCs) but not of their primed counterpart. Surprisingly, this increased proliferation, dependent on the CB1 receptor binding, is only associated with moderate transcriptomic changes. Instead, Δ9-THC capitalizes on ESCs’ metabolic bivalence by increasing their glycolytic rates and anabolic capabilities. A memory of this metabolic rewiring is retained throughout differentiation to Primordial Germ Cell-Like Cells in the absence of direct exposure and is associated with an alteration of their transcriptional profile. These results represent the first in-depth molecular characterization of the impact of Δ9-THC exposure on early developmental stages." @default.
- W4384130147 created "2023-07-14" @default.
- W4384130147 creator A5005549866 @default.
- W4384130147 creator A5028687777 @default.
- W4384130147 creator A5056411655 @default.
- W4384130147 creator A5062835705 @default.
- W4384130147 creator A5088751229 @default.
- W4384130147 date "2023-07-13" @default.
- W4384130147 modified "2023-09-25" @default.
- W4384130147 title "Metabolic memory of Δ9-tetrahydrocannabinol exposure in pluripotent stem cells and primordial germ cells-like cells" @default.
- W4384130147 doi "https://doi.org/10.7554/elife.88795.1" @default.
- W4384130147 hasPublicationYear "2023" @default.
- W4384130147 type Work @default.
- W4384130147 citedByCount "0" @default.
- W4384130147 crossrefType "posted-content" @default.
- W4384130147 hasAuthorship W4384130147A5005549866 @default.
- W4384130147 hasAuthorship W4384130147A5028687777 @default.
- W4384130147 hasAuthorship W4384130147A5056411655 @default.
- W4384130147 hasAuthorship W4384130147A5062835705 @default.
- W4384130147 hasAuthorship W4384130147A5088751229 @default.
- W4384130147 hasBestOaLocation W43841301471 @default.
- W4384130147 hasConcept C104317684 @default.
- W4384130147 hasConcept C107459253 @default.
- W4384130147 hasConcept C145103041 @default.
- W4384130147 hasConcept C148001335 @default.
- W4384130147 hasConcept C150194340 @default.
- W4384130147 hasConcept C162317418 @default.
- W4384130147 hasConcept C170493617 @default.
- W4384130147 hasConcept C2776885963 @default.
- W4384130147 hasConcept C2778563155 @default.
- W4384130147 hasConcept C2780871563 @default.
- W4384130147 hasConcept C28328180 @default.
- W4384130147 hasConcept C54355233 @default.
- W4384130147 hasConcept C86803240 @default.
- W4384130147 hasConcept C95444343 @default.
- W4384130147 hasConceptScore W4384130147C104317684 @default.
- W4384130147 hasConceptScore W4384130147C107459253 @default.
- W4384130147 hasConceptScore W4384130147C145103041 @default.
- W4384130147 hasConceptScore W4384130147C148001335 @default.
- W4384130147 hasConceptScore W4384130147C150194340 @default.
- W4384130147 hasConceptScore W4384130147C162317418 @default.
- W4384130147 hasConceptScore W4384130147C170493617 @default.
- W4384130147 hasConceptScore W4384130147C2776885963 @default.
- W4384130147 hasConceptScore W4384130147C2778563155 @default.
- W4384130147 hasConceptScore W4384130147C2780871563 @default.
- W4384130147 hasConceptScore W4384130147C28328180 @default.
- W4384130147 hasConceptScore W4384130147C54355233 @default.
- W4384130147 hasConceptScore W4384130147C86803240 @default.
- W4384130147 hasConceptScore W4384130147C95444343 @default.
- W4384130147 hasLocation W43841301471 @default.
- W4384130147 hasLocation W43841301472 @default.
- W4384130147 hasOpenAccess W4384130147 @default.
- W4384130147 hasPrimaryLocation W43841301471 @default.
- W4384130147 hasRelatedWork W1998450540 @default.
- W4384130147 hasRelatedWork W2005187038 @default.
- W4384130147 hasRelatedWork W2025569286 @default.
- W4384130147 hasRelatedWork W2037985816 @default.
- W4384130147 hasRelatedWork W2138424768 @default.
- W4384130147 hasRelatedWork W2274785012 @default.
- W4384130147 hasRelatedWork W2768952912 @default.
- W4384130147 hasRelatedWork W3029521944 @default.
- W4384130147 hasRelatedWork W3121956243 @default.
- W4384130147 hasRelatedWork W3138500615 @default.
- W4384130147 isParatext "false" @default.
- W4384130147 isRetracted "false" @default.
- W4384130147 workType "article" @default.