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- W4384130421 abstract "Abstract The emergence of retinal progenitor cells (RPCs) and differentiation to various retinal cell types represent fundamental processes during retinal development. Herein, we provide a comprehensive single cell characterisation of transcriptional and chromatin accessibility changes that underline RPC specification and differentiation over the course of human retinal development up to midgestation. Our lineage trajectory data demonstrate the presence of early RPCs, which transit to late RPCs, and further to transient neurogenic progenitors, that give rise to all the retinal neurons. Combining single cell RNA-Seq with spatial transcriptomics of early eye samples, we demonstrate for the first time the transient presence of early RPCs in the ciliary margin zone with decreasing occurrence from 8 PCW of human development. In RPCs, we identified a significant enrichment for TEAD transcription factor binding motifs, which when inhibited led to loss of RPCs and retinal lamination, and inhibition of photoreceptor and retinal ganglion cell differentiation." @default.
- W4384130421 created "2023-07-14" @default.
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- W4384130421 date "2023-07-13" @default.
- W4384130421 modified "2023-09-25" @default.
- W4384130421 title "Spatiotemporal single cell analyses reveal a transient population of retinal progenitor cells in the ciliary margin of developing human retina" @default.
- W4384130421 doi "https://doi.org/10.21203/rs.3.rs-3160527/v1" @default.
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