Matches in SemOpenAlex for { <https://semopenalex.org/work/W4384131009> ?p ?o ?g. }
- W4384131009 endingPage "1968" @default.
- W4384131009 startingPage "1968" @default.
- W4384131009 abstract "Glioblastoma is an aggressive brain tumor with an average life expectancy between 14 and 16 months after diagnosis. The Ki-67 labeling index (LI), a measure of cellular proliferation, is emerging as a prognostic marker in GBM. In this study, we investigated the ultrastructure of glioblastoma tissue from 9 patients with the same molecular profile (adult IDH wild-type glioblastoma, wild-type ATRX, and positive for TP53 expression, GFAP expression, and EGFR overexpression) to find possible ultrastructural features to be used as biomarkers and correlated with the only parameter that differs among our samples, the Ki-67 LI. Our main results were the visualization of the anatomical basis of astrocyte-endothelial cells crosstalk; the ultrastructural in situ imaging of clusters of hyperactivated microglia cells (MsEVs); the ultrastructural in situ imaging of microglia cells storing lipid vesicles (MsLVs); the ultrastructural in situ imaging of neoplastic cells mitophagy (NCsM). The statistical analysis of our data indicated that MsEVs and MsLVs correlate with the Ki-67 LI value. We can thus assume they are good candidates to be considered morphological biomarkers correlating to Ki-67 LI. The role of NCsM instead must be further evaluated. Our study findings demonstrate that by combining ultrastructural characteristics with molecular information, we can discover biomarkers that have the potential to enhance diagnostic precision, aid in treatment decision-making, identify targets for therapy, and enable personalized treatment plans tailored to each patient. However, further research with larger sample sizes is needed to validate these findings and fully utilize the potential of ultrastructural analysis in managing glioblastoma." @default.
- W4384131009 created "2023-07-14" @default.
- W4384131009 creator A5009372916 @default.
- W4384131009 creator A5013436029 @default.
- W4384131009 creator A5022135505 @default.
- W4384131009 creator A5024770382 @default.
- W4384131009 creator A5031323777 @default.
- W4384131009 creator A5033999588 @default.
- W4384131009 creator A5036040057 @default.
- W4384131009 creator A5038412313 @default.
- W4384131009 creator A5051765260 @default.
- W4384131009 creator A5057343471 @default.
- W4384131009 creator A5058647288 @default.
- W4384131009 creator A5066199348 @default.
- W4384131009 creator A5066350451 @default.
- W4384131009 date "2023-07-12" @default.
- W4384131009 modified "2023-10-18" @default.
- W4384131009 title "Adult IDH Wild-Type Glioblastoma Ultrastructural Investigation Suggests a Possible Correlation between Morphological Biomarkers and Ki-67 Index" @default.
- W4384131009 cites W146902904 @default.
- W4384131009 cites W147086652 @default.
- W4384131009 cites W1872071454 @default.
- W4384131009 cites W1921809757 @default.
- W4384131009 cites W1984557698 @default.
- W4384131009 cites W1986092833 @default.
- W4384131009 cites W1992352812 @default.
- W4384131009 cites W1996024251 @default.
- W4384131009 cites W2003674452 @default.
- W4384131009 cites W2019154144 @default.
- W4384131009 cites W2023353150 @default.
- W4384131009 cites W2030701238 @default.
- W4384131009 cites W2040423913 @default.
- W4384131009 cites W2084761937 @default.
- W4384131009 cites W2108933679 @default.
- W4384131009 cites W2117996853 @default.
- W4384131009 cites W2122261182 @default.
- W4384131009 cites W2124677738 @default.
- W4384131009 cites W2129769331 @default.
- W4384131009 cites W2132308700 @default.
- W4384131009 cites W2142772228 @default.
- W4384131009 cites W2148372334 @default.
- W4384131009 cites W2150767029 @default.
- W4384131009 cites W2154536753 @default.
- W4384131009 cites W2155268547 @default.
- W4384131009 cites W2208036228 @default.
- W4384131009 cites W2212334442 @default.
- W4384131009 cites W2256955303 @default.
- W4384131009 cites W2295495604 @default.
- W4384131009 cites W2336534940 @default.
- W4384131009 cites W2366536035 @default.
- W4384131009 cites W2417662509 @default.
- W4384131009 cites W2469066829 @default.
- W4384131009 cites W2517107066 @default.
- W4384131009 cites W2527645962 @default.
- W4384131009 cites W2586411855 @default.
- W4384131009 cites W2618992230 @default.
- W4384131009 cites W2737157719 @default.
- W4384131009 cites W2751562530 @default.
- W4384131009 cites W2760019720 @default.
- W4384131009 cites W2769071992 @default.
- W4384131009 cites W2781995688 @default.
- W4384131009 cites W2783146090 @default.
- W4384131009 cites W2790128577 @default.
- W4384131009 cites W2790178097 @default.
- W4384131009 cites W2794709042 @default.
- W4384131009 cites W2885582506 @default.
- W4384131009 cites W2890896123 @default.
- W4384131009 cites W2899404517 @default.
- W4384131009 cites W2910867640 @default.
- W4384131009 cites W2911333477 @default.
- W4384131009 cites W2915143400 @default.
- W4384131009 cites W2953102624 @default.
- W4384131009 cites W2988510873 @default.
- W4384131009 cites W2996422462 @default.
- W4384131009 cites W3000061011 @default.
- W4384131009 cites W3000070300 @default.
- W4384131009 cites W3005474073 @default.
- W4384131009 cites W3007178385 @default.
- W4384131009 cites W3008430853 @default.
- W4384131009 cites W3033495061 @default.
- W4384131009 cites W3037633958 @default.
- W4384131009 cites W3042523714 @default.
- W4384131009 cites W3047475497 @default.
- W4384131009 cites W3086050495 @default.
- W4384131009 cites W3118864881 @default.
- W4384131009 cites W3127042969 @default.
- W4384131009 cites W3127193352 @default.
- W4384131009 cites W3129615438 @default.
- W4384131009 cites W3130578067 @default.
- W4384131009 cites W3131202669 @default.
- W4384131009 cites W3137717232 @default.
- W4384131009 cites W3151811065 @default.
- W4384131009 cites W3156308715 @default.
- W4384131009 cites W3165007657 @default.
- W4384131009 cites W3174246647 @default.
- W4384131009 cites W3183766302 @default.
- W4384131009 cites W3190282823 @default.
- W4384131009 cites W3198212650 @default.
- W4384131009 cites W3198989450 @default.