Matches in SemOpenAlex for { <https://semopenalex.org/work/W4384131025> ?p ?o ?g. }
- W4384131025 abstract "Cerebellar Purkinje cells (PCs) encode movement kinematics in their population firing rates. Firing rate suppression is hypothesized to disinhibit neurons in the cerebellar nuclei, promoting adaptive movement adjustments. Debates persist, however, about whether a second disinhibitory mechanism, PC simple spike synchrony, is a relevant population code. We addressed this question by relating PC rate and synchrony patterns recorded with high density probes, to mouse reach kinematics. We discovered behavioral correlates of PC synchrony that align with a known causal relationship between activity in cerebellar output. Reach deceleration was positively correlated with both Purkinje firing rate decreases and synchrony, consistent with both mechanisms disinhibiting target neurons, which are known to adjust reach velocity. Direct tests of the contribution of each coding scheme to nuclear firing using dynamic clamp, combining physiological rate and synchrony patterns ex vivo, confirmed that physiological levels of PC simple spike synchrony are highly facilitatory for nuclear firing. These findings suggest that PC firing rate and synchrony collaborate to exert fine control of movement." @default.
- W4384131025 created "2023-07-14" @default.
- W4384131025 creator A5041944180 @default.
- W4384131025 creator A5060555402 @default.
- W4384131025 creator A5079845877 @default.
- W4384131025 creator A5091012126 @default.
- W4384131025 date "2023-07-12" @default.
- W4384131025 modified "2023-09-30" @default.
- W4384131025 title "A dual Purkinje cell rate and synchrony code sculpts reach kinematics" @default.
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- W4384131025 doi "https://doi.org/10.1101/2023.07.12.548720" @default.
- W4384131025 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37503038" @default.
- W4384131025 hasPublicationYear "2023" @default.
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