Matches in SemOpenAlex for { <https://semopenalex.org/work/W4384132052> ?p ?o ?g. }
Showing items 1 to 72 of
72
with 100 items per page.
- W4384132052 abstract "Asymmetric cell divisions (ACDs) generate two daughter cells with identical genetic information but distinct cell fates through epigenetic mechanisms. However, the process of partitioning different epigenetic information into daughter cells remains unclear. Here, we demonstrate that the nucleosome remodeling and deacetylase (NuRD) complex is asymmetrically segregated into the surviving daughter cell rather than the apoptotic one during ACDs in Caenorhabditis elegans. The absence of NuRD triggers apoptosis via the EGL-1-CED-9-CED-4-CED-3 pathway, while an ectopic gain of NuRD enables apoptotic daughter cells to survive. We identify the vacuolar H+–adenosine triphosphatase (V-ATPase) complex as a crucial regulator of NuRD’s asymmetric segregation. V-ATPase interacts with NuRD and is asymmetrically segregated into the surviving daughter cell. Inhibition of V-ATPase disrupts cytosolic pH asymmetry and NuRD asymmetry. We suggest that asymmetric segregation of V-ATPase may cause distinct acidification levels in the two daughter cells, enabling asymmetric epigenetic inheritance that specifies their respective life-versus-death fates." @default.
- W4384132052 created "2023-07-14" @default.
- W4384132052 creator A5004657400 @default.
- W4384132052 creator A5006350000 @default.
- W4384132052 creator A5022384185 @default.
- W4384132052 creator A5029505084 @default.
- W4384132052 creator A5041723537 @default.
- W4384132052 creator A5064699361 @default.
- W4384132052 creator A5084028363 @default.
- W4384132052 creator A5084108567 @default.
- W4384132052 creator A5085408126 @default.
- W4384132052 date "2023-07-13" @default.
- W4384132052 modified "2023-10-11" @default.
- W4384132052 title "Vacuolar H+-ATPase Determines Daughter Cell Fates through Asymmetric Segregation of the Nucleosome Remodeling and Deacetylase Complex" @default.
- W4384132052 doi "https://doi.org/10.7554/elife.89032.1" @default.
- W4384132052 hasPublicationYear "2023" @default.
- W4384132052 type Work @default.
- W4384132052 citedByCount "0" @default.
- W4384132052 crossrefType "posted-content" @default.
- W4384132052 hasAuthorship W4384132052A5004657400 @default.
- W4384132052 hasAuthorship W4384132052A5006350000 @default.
- W4384132052 hasAuthorship W4384132052A5022384185 @default.
- W4384132052 hasAuthorship W4384132052A5029505084 @default.
- W4384132052 hasAuthorship W4384132052A5041723537 @default.
- W4384132052 hasAuthorship W4384132052A5064699361 @default.
- W4384132052 hasAuthorship W4384132052A5084028363 @default.
- W4384132052 hasAuthorship W4384132052A5084108567 @default.
- W4384132052 hasAuthorship W4384132052A5085408126 @default.
- W4384132052 hasBestOaLocation W43841320521 @default.
- W4384132052 hasConcept C104317684 @default.
- W4384132052 hasConcept C1491633281 @default.
- W4384132052 hasConcept C181199279 @default.
- W4384132052 hasConcept C23265538 @default.
- W4384132052 hasConcept C2778305200 @default.
- W4384132052 hasConcept C2778944004 @default.
- W4384132052 hasConcept C41091548 @default.
- W4384132052 hasConcept C54355233 @default.
- W4384132052 hasConcept C55493867 @default.
- W4384132052 hasConcept C64927066 @default.
- W4384132052 hasConcept C85813293 @default.
- W4384132052 hasConcept C86803240 @default.
- W4384132052 hasConcept C95444343 @default.
- W4384132052 hasConceptScore W4384132052C104317684 @default.
- W4384132052 hasConceptScore W4384132052C1491633281 @default.
- W4384132052 hasConceptScore W4384132052C181199279 @default.
- W4384132052 hasConceptScore W4384132052C23265538 @default.
- W4384132052 hasConceptScore W4384132052C2778305200 @default.
- W4384132052 hasConceptScore W4384132052C2778944004 @default.
- W4384132052 hasConceptScore W4384132052C41091548 @default.
- W4384132052 hasConceptScore W4384132052C54355233 @default.
- W4384132052 hasConceptScore W4384132052C55493867 @default.
- W4384132052 hasConceptScore W4384132052C64927066 @default.
- W4384132052 hasConceptScore W4384132052C85813293 @default.
- W4384132052 hasConceptScore W4384132052C86803240 @default.
- W4384132052 hasConceptScore W4384132052C95444343 @default.
- W4384132052 hasLocation W43841320521 @default.
- W4384132052 hasLocation W43841320522 @default.
- W4384132052 hasOpenAccess W4384132052 @default.
- W4384132052 hasPrimaryLocation W43841320521 @default.
- W4384132052 hasRelatedWork W1540983225 @default.
- W4384132052 hasRelatedWork W2006824440 @default.
- W4384132052 hasRelatedWork W2053939460 @default.
- W4384132052 hasRelatedWork W2141850041 @default.
- W4384132052 hasRelatedWork W2550479461 @default.
- W4384132052 hasRelatedWork W2610256214 @default.
- W4384132052 hasRelatedWork W2884443433 @default.
- W4384132052 hasRelatedWork W2937983640 @default.
- W4384132052 hasRelatedWork W3026860180 @default.
- W4384132052 hasRelatedWork W3183075330 @default.
- W4384132052 isParatext "false" @default.
- W4384132052 isRetracted "false" @default.
- W4384132052 workType "article" @default.