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- W4384133265 abstract "Metastasis to the brain occurs in a significant fraction of patients with breast cancer and in patients with lung cancer (1-3). We mined publicly available multiplexed gene expression and published microarray data (4, 5) to compare primary and metastatic tumor gene expression profiles for the discovery of genes associated with brain metastasis in humans with metastatic lung cancer and metastatic breast cancer. We found that selectin E, encoded by SELE, was among the genes whose expression was most different in the brain metastases of patients with metastatic lung cancer as compared to primary tumors of the lung. SELE mRNA was present at decreased quantities in lung metastatic tissues as compared to primary tumors of the breast. Study of human survival data revealed that expression of SELE in primary tumors was correlated with patient overall, distant metastasis-free and recurrence-free survival in patients with breast cancer. We recently reported differential expression of L-selectin in solid tumor patients with central nervous system metastasis6. Modulation of SELE expression may be relevant to the biology by which tumor cells metastasize from the primary organ site to the brain in patients with two major solid tumor types." @default.
- W4384133265 created "2023-07-14" @default.
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- W4384133265 date "2023-07-12" @default.
- W4384133265 modified "2023-09-25" @default.
- W4384133265 title "Differential expression of SELE in CNS metastasis." @default.
- W4384133265 doi "https://doi.org/10.31219/osf.io/fzyn6" @default.
- W4384133265 hasPublicationYear "2023" @default.
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