FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4384133448> ?p ?o ?g. }

• W4384133448 abstract "Systematic review and evaluation of the mechanistic evidence only recently been instituted in cancer hazard identification step of decision-making. One example of organizing and evaluating mechanistic evidence is the Key Characteristics approach of the International Agency for Research on Cancer (IARC) Monographs on the Identification of Carcinogenic Hazards to Humans. The Key Characteristics of Human Carcinogens were proposed almost 10 years ago and have been used in every IARC Monograph since 2015. We investigated the patterns and associations in the use of Key Characteristics by the independent expert Working Groups. We examined 19 Monographs (2015-2022) that evaluated 73 agents. We extracted information on the conclusions by each Working Group on the strength of evidence for agent-Key Characteristic combinations, data types that were available for decisions, and the role mechanistic data played in the final cancer hazard classification. We conducted both descriptive and association analyses within and across data types. We found that IARC Working Groups were cautious when evaluating mechanistic evidence: for only ∼13% of the agents was strong evidence assigned for any Key Characteristic. Genotoxicity and cell proliferation were most data-rich, while little evidence was available for DNA repair and immortalization Key Characteristics. Analysis of the associations among Key Characteristics revealed that only chemical's metabolic activation was significantly co-occurring with genotoxicity and cell proliferation/death. Evidence from exposed humans was limited, while mechanistic evidence from rodent studies in vivo was often available. Only genotoxicity and cell proliferation/death were strongly associated with decisions on whether mechanistic data was impactful on the final cancer hazard classification. The practice of using the Key Characteristics approach is now well-established at IARC Monographs and other government agencies and the analyses presented herein will inform the future use of mechanistic evidence in regulatory decision-making." @default.
• W4384133448 created "2023-07-14" @default.
• W4384133448 creator A5016238665 @default.
• W4384133448 creator A5019868317 @default.
• W4384133448 date "2023-07-12" @default.
• W4384133448 modified "2023-09-25" @default.
• W4384133448 title "Ten Years of Using Key Characteristics of Human Carcinogens to Organize and Evaluate Mechanistic Evidence in IARC Monographs on the Identification of Carcinogenic Hazards to Humans: Patterns and Associations" @default.
• W4384133448 cites W1879098942 @default.
• W4384133448 cites W1906935673 @default.
• W4384133448 cites W1968443518 @default.
• W4384133448 cites W1974068770 @default.
• W4384133448 cites W1976750784 @default.
• W4384133448 cites W1988805205 @default.
• W4384133448 cites W1990878286 @default.
• W4384133448 cites W2077579733 @default.
• W4384133448 cites W2090058128 @default.
• W4384133448 cites W2100631636 @default.
• W4384133448 cites W2106600513 @default.
• W4384133448 cites W2112047061 @default.
• W4384133448 cites W2117202998 @default.
• W4384133448 cites W2117692326 @default.
• W4384133448 cites W2118003508 @default.
• W4384133448 cites W2122025333 @default.
• W4384133448 cites W2131272087 @default.
• W4384133448 cites W2141680945 @default.
• W4384133448 cites W2146976723 @default.
• W4384133448 cites W2155491988 @default.
• W4384133448 cites W2162023820 @default.
• W4384133448 cites W2173513074 @default.
• W4384133448 cites W2194873522 @default.
• W4384133448 cites W2267302592 @default.
• W4384133448 cites W2291686380 @default.
• W4384133448 cites W2326278212 @default.
• W4384133448 cites W2583238910 @default.
• W4384133448 cites W2592470974 @default.
• W4384133448 cites W2594519269 @default.
• W4384133448 cites W2751320415 @default.
• W4384133448 cites W2765816881 @default.
• W4384133448 cites W2769853272 @default.
• W4384133448 cites W2790301404 @default.
• W4384133448 cites W2794565592 @default.
• W4384133448 cites W2810311698 @default.
• W4384133448 cites W2811077318 @default.
• W4384133448 cites W2896493253 @default.
• W4384133448 cites W2919637418 @default.
• W4384133448 cites W2951922583 @default.
• W4384133448 cites W2961191798 @default.
• W4384133448 cites W2965686296 @default.
• W4384133448 cites W2972927651 @default.
• W4384133448 cites W2981667486 @default.
• W4384133448 cites W2982038441 @default.
• W4384133448 cites W2985810567 @default.
• W4384133448 cites W2992543001 @default.
• W4384133448 cites W2995593899 @default.
• W4384133448 cites W3097280976 @default.
• W4384133448 cites W3112394955 @default.
• W4384133448 cites W3149778443 @default.
• W4384133448 cites W3172904256 @default.
• W4384133448 cites W3212971182 @default.
• W4384133448 cites W4200318509 @default.
• W4384133448 cites W4211062592 @default.
• W4384133448 cites W4229791719 @default.
• W4384133448 cites W4240398535 @default.
• W4384133448 cites W4302362343 @default.
• W4384133448 cites W4307656947 @default.
• W4384133448 cites W4316466034 @default.
• W4384133448 cites W4366351813 @default.
• W4384133448 doi "https://doi.org/10.1101/2023.07.11.548354" @default.
• W4384133448 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37503163" @default.
• W4384133448 hasPublicationYear "2023" @default.
• W4384133448 type Work @default.
• W4384133448 citedByCount "0" @default.
• W4384133448 crossrefType "posted-content" @default.
• W4384133448 hasAuthorship W4384133448A5016238665 @default.
• W4384133448 hasAuthorship W4384133448A5019868317 @default.
• W4384133448 hasBestOaLocation W43841334481 @default.
• W4384133448 hasConcept C114246631 @default.
• W4384133448 hasConcept C116834253 @default.
• W4384133448 hasConcept C121608353 @default.
• W4384133448 hasConcept C126322002 @default.
• W4384133448 hasConcept C18903297 @default.
• W4384133448 hasConcept C26517878 @default.
• W4384133448 hasConcept C2778959862 @default.
• W4384133448 hasConcept C29730261 @default.
• W4384133448 hasConcept C2993769243 @default.
• W4384133448 hasConcept C33070731 @default.
• W4384133448 hasConcept C49261128 @default.
• W4384133448 hasConcept C54355233 @default.
• W4384133448 hasConcept C59822182 @default.
• W4384133448 hasConcept C71924100 @default.
• W4384133448 hasConcept C86803240 @default.
• W4384133448 hasConceptScore W4384133448C114246631 @default.
• W4384133448 hasConceptScore W4384133448C116834253 @default.
• W4384133448 hasConceptScore W4384133448C121608353 @default.
• W4384133448 hasConceptScore W4384133448C126322002 @default.
• W4384133448 hasConceptScore W4384133448C18903297 @default.
• W4384133448 hasConceptScore W4384133448C26517878 @default.
• W4384133448 hasConceptScore W4384133448C2778959862 @default.
• W4384133448 hasConceptScore W4384133448C29730261 @default.
• W4384133448 hasConceptScore W4384133448C2993769243 @default.

• next