FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4384133526> ?p ?o ?g. }

• W4384133526 abstract "Abstract Although increasing studies has demonstrated that cell competition widely involved in the growth and homeostasis of multicellular organisms is closely linked to tumorigenesis and development, the mechanistic contributions to the association between tumor cell competition-driven heterogeneity and drug resistance remains ill-defined. In our study, lenvitinib-resistant hepatocellular carcinoma (HCC) cells display obviously competitive growth dominance against sensitive cells through reprogramming energy metabolism. Mechanistically, when BCL2 interacting protein3 (BNIP3) overexpression activates mitophagy activity in lenvatinib-resistant HCC cells, energy imbalance signal caused by reduced mitochondrial oxidative phosphorylation levels provokes the phosphorylation of AMP-activated protein kinase (AMPK) sensor; subsequently, enabled AMPK specifically targets enolase 2 (ENO2) to enhance glycolysis and eventually promots the competitive capacity and dominant growth. Of note, BNIP3 deficiency shows certain inhibition of cell competition outcome. Our findings emphasize a vital role for BNIP3-AMPK-ENO2 signaling in maintaining the competitive outcome of lenvitinib-resistant HCC cells via regulating energy metabolism; meanwhile this work recognaizes BNIP3 as a promising target to overcome HCC drug resistance." @default.
• W4384133526 created "2023-07-14" @default.
• W4384133526 creator A5030891359 @default.
• W4384133526 creator A5042365006 @default.
• W4384133526 creator A5048703887 @default.
• W4384133526 creator A5058481549 @default.
• W4384133526 creator A5079615657 @default.
• W4384133526 creator A5083603048 @default.
• W4384133526 creator A5087710996 @default.
• W4384133526 creator A5090950831 @default.
• W4384133526 date "2023-07-12" @default.
• W4384133526 modified "2023-09-27" @default.
• W4384133526 title "BNIP3-mediated mitophagy boosts the competitive dominant growth of lenvatinib resistant cells via reprogramming energy metabolism in HCC" @default.
• W4384133526 cites W1627187635 @default.
• W4384133526 cites W1659738267 @default.
• W4384133526 cites W1691578538 @default.
• W4384133526 cites W1908788336 @default.
• W4384133526 cites W1968478185 @default.
• W4384133526 cites W1989670144 @default.
• W4384133526 cites W1993790646 @default.
• W4384133526 cites W1997474381 @default.
• W4384133526 cites W1999574084 @default.
• W4384133526 cites W2000542942 @default.
• W4384133526 cites W2014122199 @default.
• W4384133526 cites W2017073557 @default.
• W4384133526 cites W2027468963 @default.
• W4384133526 cites W2039898135 @default.
• W4384133526 cites W2042696326 @default.
• W4384133526 cites W2069448970 @default.
• W4384133526 cites W2069924572 @default.
• W4384133526 cites W2076031927 @default.
• W4384133526 cites W2081495016 @default.
• W4384133526 cites W2086235418 @default.
• W4384133526 cites W2102278945 @default.
• W4384133526 cites W2109011367 @default.
• W4384133526 cites W2117692326 @default.
• W4384133526 cites W2139760555 @default.
• W4384133526 cites W2146776550 @default.
• W4384133526 cites W2163067447 @default.
• W4384133526 cites W2163471981 @default.
• W4384133526 cites W2170551349 @default.
• W4384133526 cites W2254049738 @default.
• W4384133526 cites W2316599784 @default.
• W4384133526 cites W2525290462 @default.
• W4384133526 cites W2558729727 @default.
• W4384133526 cites W2755721896 @default.
• W4384133526 cites W2787358630 @default.
• W4384133526 cites W2809889937 @default.
• W4384133526 cites W2811236673 @default.
• W4384133526 cites W2895302001 @default.
• W4384133526 cites W2899560692 @default.
• W4384133526 cites W2912300441 @default.
• W4384133526 cites W2913043277 @default.
• W4384133526 cites W2932503900 @default.
• W4384133526 cites W2946002697 @default.
• W4384133526 cites W2958645511 @default.
• W4384133526 cites W2968357783 @default.
• W4384133526 cites W2972474548 @default.
• W4384133526 cites W3012044792 @default.
• W4384133526 cites W3013377779 @default.
• W4384133526 cites W3025022288 @default.
• W4384133526 cites W3025750832 @default.
• W4384133526 cites W3045212800 @default.
• W4384133526 cites W3048102544 @default.
• W4384133526 cites W3048331025 @default.
• W4384133526 cites W3097601159 @default.
• W4384133526 cites W3110766076 @default.
• W4384133526 cites W3118474404 @default.
• W4384133526 cites W3118635735 @default.
• W4384133526 cites W3123285134 @default.
• W4384133526 cites W3133221794 @default.
• W4384133526 cites W3137598021 @default.
• W4384133526 cites W3165366231 @default.
• W4384133526 cites W3165875563 @default.
• W4384133526 cites W3181504157 @default.
• W4384133526 cites W3185937604 @default.
• W4384133526 cites W3190658316 @default.
• W4384133526 cites W4206287336 @default.
• W4384133526 cites W4206802451 @default.
• W4384133526 cites W4211140416 @default.
• W4384133526 cites W4223607161 @default.
• W4384133526 cites W4297996266 @default.
• W4384133526 cites W4304175279 @default.
• W4384133526 doi "https://doi.org/10.1101/2023.07.12.548688" @default.
• W4384133526 hasPublicationYear "2023" @default.
• W4384133526 type Work @default.
• W4384133526 citedByCount "0" @default.
• W4384133526 crossrefType "posted-content" @default.
• W4384133526 hasAuthorship W4384133526A5030891359 @default.
• W4384133526 hasAuthorship W4384133526A5042365006 @default.
• W4384133526 hasAuthorship W4384133526A5048703887 @default.
• W4384133526 hasAuthorship W4384133526A5058481549 @default.
• W4384133526 hasAuthorship W4384133526A5079615657 @default.
• W4384133526 hasAuthorship W4384133526A5083603048 @default.
• W4384133526 hasAuthorship W4384133526A5087710996 @default.
• W4384133526 hasAuthorship W4384133526A5090950831 @default.
• W4384133526 hasBestOaLocation W43841335261 @default.
• W4384133526 hasConcept C1491633281 @default.
• W4384133526 hasConcept C184235292 @default.
• W4384133526 hasConcept C190283241 @default.

• next