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- W4384133695 abstract "Abstract Persistence ensures continuity in a course of action. It is crucial to human success and animal survival. However, how the brain applies persistence to movements is unknown. Here we demonstrate that persistence arises during the initial phase of movement and is maintained until terminal signaling. Using single-unit extracellular recordings in awake mice, we found that neural encoding of persistent movement phases is independent of the valuation (i.e., valence) of the external stimuli. Next, using opto-tagging, we identified a group of dorsal medial prefrontal cortex (dmPFC) motor cortex projecting (MP) neurons, which encodes the initial phase of a persistent movement rather than valence. Inactivation of dmPFC MP neurons impairs the initiation of persistence and reduces neuronal activity in the insular and motor cortex. Finally, a computational model suggests that a successive sensory stimulus acts as a triggering signal for the initiation of persistent movements. These results reveal a neural mechanism that switches the brain state from neutral to persistent during movement." @default.
- W4384133695 created "2023-07-14" @default.
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- W4384133695 date "2023-07-12" @default.
- W4384133695 modified "2023-09-25" @default.
- W4384133695 title "A prefrontal motor circuit initiates persistent movement" @default.
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- W4384133695 doi "https://doi.org/10.1101/2023.07.11.548619" @default.
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