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- W4384133762 abstract "In the current article, Miles et al, (Circulation 2023;147:1622; PMID: 372164370) provides a timely review of Brugada syndrome (BrS), early repolarization syndrome (ERS), and idiopathic ventricular fibrillation (iVF), that have long been considered primary electrical disorders associated with malignant ventricular arrhythmia and sudden cardiac death. Recent studies have revealed the presence of subtle microstructural abnormalities of the extracellular matrix in some cases of BrS, ERS, and iVF, particularly within right ventricular subepicardial myocardium. Patients with ERS and iVF may also exhibit low-voltage and fractionated electrograms in the ventricular subepicardial myocardium, which can be treated with ablation. A significant proportion of patients harbor pathogenic variants in the voltage-gated sodium channel gene, SCN5A, but the majority of patients are likely to be polygenic. The authors conclude that BrS, ERS, and iVF may form part of a spectrum of subtle subepicardial cardiomyopathy with impaired sodium current, along with genetic and environmental susceptibility." @default.
- W4384133762 created "2023-07-14" @default.
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- W4384133762 date "2023-09-01" @default.
- W4384133762 modified "2023-09-25" @default.
- W4384133762 title "EP News: Basic and Translational" @default.
- W4384133762 doi "https://doi.org/10.1016/j.hrthm.2023.07.009" @default.
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