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- W4384133823 endingPage "121944" @default.
- W4384133823 startingPage "121944" @default.
- W4384133823 abstract "The relation between obesity and osteoarthritis (OA) development has been traditionally explained as consequence of the excessive joint effort derived of overweight. However, in the last two decades a metabolic OA has been suggested through diverse molecular mechanism implying metabolic syndrome, although more investigation must be conducted to elucidate it. Metabolic syndrome is responsible of the release of diverse inflammatory cytokines, specially the increased adipokine in obesity, causing a chronic low-grade inflammatory status that alters the joint homeostasis. In this scenario, the microbiota dysbiosis contribute by worsening the low-grade chronic inflammation or causing metabolic disorders mediated by endotoxemia generated by an increased lipopolysaccharides intake. This results in joint inflammation and cartilage degradation, which contributes to the development of OA. Also, the insulin resistance provoked by type 2 Diabetes contributes to the OA development. When intake patterns are considered, some coincidences can be pointed between the food patterns associated to the metabolic syndrome and the food patterns associated to OA development. Therefore, these coincidences support the idea of a molecular mechanism of the OA development caused by the molecular mechanism generated under the metabolic syndrome status. This review points the relation between metabolic syndrome and OA, showing the connected molecular mechanisms between both pathologies as well as the shared dietary patterns that promote or prevent both pathologies." @default.
- W4384133823 created "2023-07-14" @default.
- W4384133823 creator A5008735989 @default.
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- W4384133823 creator A5067155002 @default.
- W4384133823 creator A5075900795 @default.
- W4384133823 creator A5092458901 @default.
- W4384133823 date "2023-09-01" @default.
- W4384133823 modified "2023-09-25" @default.
- W4384133823 title "The microbiota-metabolic syndrome axis as a promoter of metabolic osteoarthritis" @default.
- W4384133823 cites W1963656270 @default.
- W4384133823 cites W1971918460 @default.
- W4384133823 cites W1988950717 @default.
- W4384133823 cites W2011188889 @default.
- W4384133823 cites W2020671122 @default.
- W4384133823 cites W2021361399 @default.
- W4384133823 cites W2036752543 @default.
- W4384133823 cites W2051882491 @default.
- W4384133823 cites W2060456225 @default.
- W4384133823 cites W2066419314 @default.
- W4384133823 cites W2078579568 @default.
- W4384133823 cites W2078853951 @default.
- W4384133823 cites W2089526417 @default.
- W4384133823 cites W2091184713 @default.
- W4384133823 cites W2116946345 @default.
- W4384133823 cites W2134949545 @default.
- W4384133823 cites W2145690342 @default.
- W4384133823 cites W2150700606 @default.
- W4384133823 cites W2154353013 @default.
- W4384133823 cites W2163210664 @default.
- W4384133823 cites W2167283659 @default.
- W4384133823 cites W2189948118 @default.
- W4384133823 cites W2216020715 @default.
- W4384133823 cites W2270478562 @default.
- W4384133823 cites W2272721999 @default.
- W4384133823 cites W2286886248 @default.
- W4384133823 cites W2288508021 @default.
- W4384133823 cites W2291926443 @default.
- W4384133823 cites W2326247367 @default.
- W4384133823 cites W2338789173 @default.
- W4384133823 cites W2341421317 @default.
- W4384133823 cites W2398417419 @default.
- W4384133823 cites W2409997510 @default.
- W4384133823 cites W2410413380 @default.
- W4384133823 cites W2462653362 @default.
- W4384133823 cites W2518854129 @default.
- W4384133823 cites W2531309301 @default.
- W4384133823 cites W2546540530 @default.
- W4384133823 cites W2567777408 @default.
- W4384133823 cites W2584503597 @default.
- W4384133823 cites W2599610907 @default.
- W4384133823 cites W2604174049 @default.
- W4384133823 cites W2606800637 @default.
- W4384133823 cites W2743705181 @default.
- W4384133823 cites W2745355455 @default.
- W4384133823 cites W2753143217 @default.
- W4384133823 cites W2774743973 @default.
- W4384133823 cites W2775926107 @default.
- W4384133823 cites W2782896953 @default.
- W4384133823 cites W2791340232 @default.
- W4384133823 cites W2796174206 @default.
- W4384133823 cites W2799337008 @default.
- W4384133823 cites W2799348059 @default.
- W4384133823 cites W2809942793 @default.
- W4384133823 cites W2811010140 @default.
- W4384133823 cites W2906601223 @default.
- W4384133823 cites W2909714350 @default.
- W4384133823 cites W2920165127 @default.
- W4384133823 cites W2937319242 @default.
- W4384133823 cites W2947430334 @default.
- W4384133823 cites W2951964451 @default.
- W4384133823 cites W2955846833 @default.
- W4384133823 cites W2969924221 @default.
- W4384133823 cites W2974596468 @default.
- W4384133823 cites W2975137453 @default.
- W4384133823 cites W2981697829 @default.
- W4384133823 cites W2991876312 @default.
- W4384133823 cites W2998493880 @default.
- W4384133823 cites W2998542386 @default.
- W4384133823 cites W3000195549 @default.
- W4384133823 cites W3005859674 @default.
- W4384133823 cites W3006713925 @default.
- W4384133823 cites W3007384063 @default.
- W4384133823 cites W3104086128 @default.
- W4384133823 cites W3123049963 @default.
- W4384133823 cites W3131289879 @default.
- W4384133823 cites W4212915417 @default.
- W4384133823 cites W4220723027 @default.
- W4384133823 cites W4220729656 @default.
- W4384133823 cites W4223547590 @default.
- W4384133823 cites W4224213947 @default.
- W4384133823 cites W4281608397 @default.
- W4384133823 cites W4281725130 @default.
- W4384133823 cites W4288035532 @default.
- W4384133823 cites W4288051090 @default.
- W4384133823 cites W4295329011 @default.
- W4384133823 cites W4297905784 @default.
- W4384133823 cites W4304128165 @default.