Matches in SemOpenAlex for { <https://semopenalex.org/work/W4384154264> ?p ?o ?g. }
- W4384154264 endingPage "15" @default.
- W4384154264 startingPage "1" @default.
- W4384154264 abstract "Interstitial inflammation is an important mechanism of pathological damage in renal injury caused by hyperuricemia. Protease-activated receptor-2 (PAR2) is a class of targets that act upstream of the PI3K/AKT/NF-κB pathway and is involved in various inflammatory diseases. We induced a hyperuricemia model in rats by adenine and ethambutol gavage in an in vivo experiment. We demonstrated that PAR2 and PI3K/AKT/NF-κB pathway expression were significantly upregulated in renal tissues, with massive inflammatory cell infiltration in the renal interstitium and renal tissue injury. Treating hyperuricemic rats with AZ3451, a selective metabotropic antagonist of PAR2, we demonstrated that PAR2 antagonism inhibited the PI3K/AKT/NF-κB pathway and attenuated tubular dilation and tubulointerstitial inflammatory cell infiltration. The phospholipid metabolism profiles provided a perfect separation between the normal and hyperuricemic rats. In addition, we also found that AZ3451 can affect phospholipid metabolism. Our work suggests that PAR2 may mediate hyperuricemia-mediated renal injury by activating the PI3K/AKT/NF-κB pathway. The PAR2 antagonist AZ3451 may be a promising therapeutic strategy for hyperuricemia-induced inflammatory responses." @default.
- W4384154264 created "2023-07-14" @default.
- W4384154264 creator A5010137179 @default.
- W4384154264 creator A5015356078 @default.
- W4384154264 creator A5019778989 @default.
- W4384154264 creator A5033656225 @default.
- W4384154264 creator A5061898990 @default.
- W4384154264 creator A5065294034 @default.
- W4384154264 creator A5077084592 @default.
- W4384154264 creator A5077266337 @default.
- W4384154264 creator A5083016192 @default.
- W4384154264 date "2023-07-13" @default.
- W4384154264 modified "2023-09-26" @default.
- W4384154264 title "Protease-Activated Receptor-2 and Phospholipid Metabolism Analysis in Hyperuricemia-Induced Renal Injury" @default.
- W4384154264 cites W1929024384 @default.
- W4384154264 cites W1985764146 @default.
- W4384154264 cites W1988572026 @default.
- W4384154264 cites W2131730936 @default.
- W4384154264 cites W2170972889 @default.
- W4384154264 cites W2254471596 @default.
- W4384154264 cites W2291472060 @default.
- W4384154264 cites W2415651303 @default.
- W4384154264 cites W2564214252 @default.
- W4384154264 cites W2576559149 @default.
- W4384154264 cites W2594583512 @default.
- W4384154264 cites W2606568709 @default.
- W4384154264 cites W2609731092 @default.
- W4384154264 cites W2626234111 @default.
- W4384154264 cites W2735527928 @default.
- W4384154264 cites W2735568802 @default.
- W4384154264 cites W2744377419 @default.
- W4384154264 cites W2767334966 @default.
- W4384154264 cites W2789006309 @default.
- W4384154264 cites W2791826477 @default.
- W4384154264 cites W2806874438 @default.
- W4384154264 cites W2938493336 @default.
- W4384154264 cites W2943098102 @default.
- W4384154264 cites W2996250016 @default.
- W4384154264 cites W2996511207 @default.
- W4384154264 cites W3001602420 @default.
- W4384154264 cites W3027742405 @default.
- W4384154264 cites W3038107489 @default.
- W4384154264 cites W3040503808 @default.
- W4384154264 cites W3107455715 @default.
- W4384154264 cites W3111449834 @default.
- W4384154264 cites W3134639138 @default.
- W4384154264 cites W3134981847 @default.
- W4384154264 cites W3135604070 @default.
- W4384154264 cites W3194570688 @default.
- W4384154264 cites W4200504220 @default.
- W4384154264 cites W4231686634 @default.
- W4384154264 doi "https://doi.org/10.1155/2023/5007488" @default.
- W4384154264 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37484603" @default.
- W4384154264 hasPublicationYear "2023" @default.
- W4384154264 type Work @default.
- W4384154264 citedByCount "0" @default.
- W4384154264 crossrefType "journal-article" @default.
- W4384154264 hasAuthorship W4384154264A5010137179 @default.
- W4384154264 hasAuthorship W4384154264A5015356078 @default.
- W4384154264 hasAuthorship W4384154264A5019778989 @default.
- W4384154264 hasAuthorship W4384154264A5033656225 @default.
- W4384154264 hasAuthorship W4384154264A5061898990 @default.
- W4384154264 hasAuthorship W4384154264A5065294034 @default.
- W4384154264 hasAuthorship W4384154264A5077084592 @default.
- W4384154264 hasAuthorship W4384154264A5077266337 @default.
- W4384154264 hasAuthorship W4384154264A5083016192 @default.
- W4384154264 hasBestOaLocation W43841542641 @default.
- W4384154264 hasConcept C126322002 @default.
- W4384154264 hasConcept C134018914 @default.
- W4384154264 hasConcept C185592680 @default.
- W4384154264 hasConcept C2776914184 @default.
- W4384154264 hasConcept C2777482532 @default.
- W4384154264 hasConcept C2779721657 @default.
- W4384154264 hasConcept C2779881121 @default.
- W4384154264 hasConcept C2780091579 @default.
- W4384154264 hasConcept C4733338 @default.
- W4384154264 hasConcept C55493867 @default.
- W4384154264 hasConcept C62478195 @default.
- W4384154264 hasConcept C71924100 @default.
- W4384154264 hasConcept C75217442 @default.
- W4384154264 hasConcept C86554907 @default.
- W4384154264 hasConcept C98274493 @default.
- W4384154264 hasConceptScore W4384154264C126322002 @default.
- W4384154264 hasConceptScore W4384154264C134018914 @default.
- W4384154264 hasConceptScore W4384154264C185592680 @default.
- W4384154264 hasConceptScore W4384154264C2776914184 @default.
- W4384154264 hasConceptScore W4384154264C2777482532 @default.
- W4384154264 hasConceptScore W4384154264C2779721657 @default.
- W4384154264 hasConceptScore W4384154264C2779881121 @default.
- W4384154264 hasConceptScore W4384154264C2780091579 @default.
- W4384154264 hasConceptScore W4384154264C4733338 @default.
- W4384154264 hasConceptScore W4384154264C55493867 @default.
- W4384154264 hasConceptScore W4384154264C62478195 @default.
- W4384154264 hasConceptScore W4384154264C71924100 @default.
- W4384154264 hasConceptScore W4384154264C75217442 @default.
- W4384154264 hasConceptScore W4384154264C86554907 @default.
- W4384154264 hasConceptScore W4384154264C98274493 @default.
- W4384154264 hasFunder F4320335966 @default.